Intranasal oxytocin attenuates the cortisol response to physical stress: A dose–response study

Cardoso, Christopher; Ellenbogen, Mark A.; Orlando, Mark Anthony; Bacon, Simon; Joober, Ridha

doi:10.1016/j.psyneuen.2012.07.013

Cited by 177 publications

(96 citation statements)

References 57 publications

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“…Considering the increased risk of crossreactivity with arginine vasopressin (AVP) receptors with higher OT doses (Åkerlund et al, 1999;Cho et al, 1999;Manning et al, 2012), which may disrupt the balance of brain OT and AVP (Neumann and Landgraf, 2012), it is important to determine if lower doses can match, or improve, the reported effects of OT (Churchland and Winkielman, 2012). Intriguingly, converging evidence from human and animal research indicates that under some circumstances, lower OT dose may offer similar or stronger effects than larger doses in comparison (Bales et al, 2013;Benelli et al, 1995;Cardoso et al, 2013;Hall et al, 2012;Popik et al, 1992;Van IJzendoorn et al, 2012). However, research is yet to comprehensively compare the impact of different IN-OT doses on social cognition and behavior.…”

Section: Resultsmentioning

confidence: 99%

Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model

Quintana

Alvares

Hickie

et al. 2015

Neuroscience & Biobehavioral Reviews

140

100

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Section: Resultsmentioning

confidence: 99%

Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model

Quintana

Alvares

Hickie

et al. 2015

Neuroscience & Biobehavioral Reviews

140

100

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“…The following were used as criteria for excluding participation: current medical illness, existing physical injury, current recreational drug use or past history of drug use (with the exception of cannabis, which required 1-year abstinence), use of current medications including psychotropic medication, history of psychiatric disorders, and prior or current use of psychological treatment services. Only participants in good physical condition were recruited to participate in the study because the larger data collection required participants to run on a treadmill for 60 minutes (Cardoso, Ellenbogen, Orlando, et al, 2013). This project was approved by the Human Research Ethics Committee at Concordia University (Montréal, Canada).…”

Section: Methods Participantsmentioning

confidence: 99%

Oxytocin and enhancement of the positive valence of social affiliation memories: An autobiographical memory study

Cardoso

Orlando

Brown

et al. 2014

Social Neuroscience

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Intranasal oxytocin has been shown to alter self-perceptions of personality (e.g., more trusting, increased extraversion). To follow up these findings, we examined the acute effects of two doses of intranasal oxytocin (24 IU and 48 IU) on another form of self-referential cognition: autobiographical memory. Changes in autobiographical memory (personal memories for the past) could conceivably effect change in self-perception and consequently alter social behaviors. We predicted that oxytocin would increase the number of specific personal memories recalled, and promote the recall of positive social affiliation memories. Seventeen male participants self-administered a placebo or oxytocin (24 IU, 48 IU) using a nasal spray on three separate occasions in a placebo-controlled, double-blind, and within-subject experiment. Participants completed the Autobiographical Memory Test (AMT) 110 minutes later. Analyses revealed a quadratic dose-response curve for the effects of intranasal oxytocin on autobiographical memory recall. The 24 IU dose, relative to the 48 IU dose and placebo, increased the number of specific personal memories recalled and promoted the recall of social affiliation memories that were rated more positively. The lack of effect with the 48 IU dose could be due to saturation of the oxytocin receptors at higher doses. Changes in autobiographical memory may be one mechanism by which oxytocin alters prosocial worldviews.

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“…Similarly, the optimal dose for an OXT IN -based intervention is still elusive. In voles, the propensity to display behaviors such as pair bonding is modulated in a dose-dependent manner (142), and in humans, 24-IU, but not 48-IU, of OXT IN attenuates cortisol levels in response to physical stress (143). The selectivity of OXT for the OXTR relative to AVPRs is at least twentyfold (cf.…”

Section: Translational Implications and New Avenues For Future Researchmentioning

confidence: 99%

Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships

Hurlemann

Scheele

2016

Biological Psychiatry

118

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Current concepts of human sociality highlight a fundamental role of the hypothalamic peptide oxytocin (OXT) in the formation and maintenance of social relationships. However, emerging evidence indicates that OXT does not invariably facilitate social bonding but also produces nonprosocial effects that may have evolved to promote offspring survival. From a mechanistic perspective, we hypothesize that OXT modulates interoceptive signals and self-referential processing, which may result in various social outcomes depending on context- and person-dependent variables such as early-life adversity. Based on this theoretical framework, we discuss translational implications for clinical trials and identify open questions for future research. Specifically, we propose that disrupted OXT signaling due to the loss of affectionate bonds may contribute to emotional disequilibrium and confer elevated risk for the onset of stress-related disorders.

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Intranasal oxytocin attenuates the cortisol response to physical stress: A dose–response study

Cited by 177 publications

References 57 publications

Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model

Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model

Oxytocin and enhancement of the positive valence of social affiliation memories: An autobiographical memory study

Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships

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