Intranasal oxytocin modulates the salience network in aging

Liu, Peiwei; Lin, Tian; Feifel, David; Ebner, Natalie C.

doi:10.1016/j.neuroimage.2022.119045

Cited by 8 publications

(6 citation statements)

References 154 publications

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“…In addition, neural correlates of OT-induced effects on decision-making and risk-taking should be explored by means of fMRI and/or EEG. In recent years, the effects of oxytocin on neuronal networks and connectivity [ 58 , 59 ] have been uncovered. In the context of cognitive functioning and decision-making, mesolimbic [ 60 ] and frontal [ 61 ] regions (especially, the ventromedial PFC [ 27 , 62 ]) are believed to play an important role, which should be evaluated in respective studies.…”

Section: Discussionmentioning

confidence: 99%

Intranasal Oxytocin Modulates Decision-Making Depending on Outcome Predictability—A Randomized Within-Subject Controlled Trial in Healthy Males

Zebhauser

Macchia²,

Gold³

et al. 2022

Biomedicines

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Oxytocin (OT) has been extensively studied with regard to its socio-cognitive and -behavioral effects. Its potential as a therapeutic agent is being discussed for a range of neuropsychiatric conditions. However, there is limited evidence of its effects on non-social cognition in general and decision-making in particular, despite the importance of these functions in neuropsychiatry. Using a crossover/within-subject, blinded, randomized design, we investigated for the first time if intranasal OT (24 IU) affects decision-making differently depending on outcome predictability/ambiguity in healthy males. The Iowa Gambling Task (IGT) and the Cambridge Risk Task (CRT) were used to assess decision-making under low outcome predictability/high ambiguity and under high outcome probability/low ambiguity, respectively. After administration of OT, subjects performed worse and exhibited riskier performance in the IGT (low outcome predictability/high ambiguity), whereas they made borderline-significant less risky decisions in the CRT (high outcome probability/low ambiguity) as compared to the control condition. Decision-making in healthy males may therefore be influenced by OT and adjusted as a function of contextual information, with implications for clinical trials investigating OT in neuropsychiatric conditions.

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Section: Discussionmentioning

confidence: 99%

Intranasal Oxytocin Modulates Decision-Making Depending on Outcome Predictability—A Randomized Within-Subject Controlled Trial in Healthy Males

Zebhauser

Macchia²,

Gold³

et al. 2022

Biomedicines

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“…Older women and men are a population understudied regarding the effect of OT on brain and behavioral function despite evidence that OT impacts functions that also change with age. For example, previous research has shown that OT modulates trust-related evaluations and decisions [7], dynamic social and emotional information processing [9,12], and functional brain networks relevant to decision-making, including the salience network and the default mode network [2,3]. Making these OT-related data publicly available is an important step toward enhancing scientific knowledge about the role of neuropeptides in shaping social cognition and social behavior in adulthood and aging [12].…”

Section: Data Descriptionmentioning

confidence: 99%

“…among other questionnaires [2][3][4]. For female participants, menstrual cycle phase data was also obtained via self-report.…”

Section: Data Descriptionmentioning

confidence: 99%

“…NCT01823146) conducted by the Social-Cognitive and Affective Development lab (PI: Dr. Natalie C. Ebner) at the University of Florida (UF)[1]. Data from this dataset has been used in publications that investigated the modulatory effect of a singledose OT intranasal administration on cognition, behavior, and neural activation/connectivity[2][3][4][5][6][7][8][9][10][11]. By sharing this data, we seek to promote open investigation into the impact of neuropeptides on the brain and behavior in adulthood and aging.…”

mentioning

confidence: 99%

“…Only the acquisition of measures provided in this dataset is described herein. Additional methods and measures are reported elsewhere[2][3][4].During an initial phone prescreening, older participants underwent the Telephone Interview for Cognitive Status to screen for cognitive decline[15]. All participants completed an MRI Eligibility Form and a study-specific Health Screening and Demographics Form to assess demographic information, present health conditions, and health history.…”

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confidence: 99%

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Single Dose Intranasal Oxytocin Administration: Data from Healthy Younger and Older Adults

Horta,

Polk,

Ebner

2023

Preprint

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Oxytocin (OT) is a neuropeptide critically involved in social cognition and behavior. Intranasal administration of OT has modulatory effects on both brain and behavior, with potential for therapeutic benefit, especially in individuals with deficits in socioemotional functions. Intranasal OT effects have been well-investigated in younger adults as well as in a variety of clinical populations (e.g., autism, schizophrenia), but there is comparatively less investigation of its function in older adults. To foster more research on OT and aging, the following dataset was made publicly available, which includes data from generally healthy younger (n = 52; aged 18-31 years; 48% female) and older adults (n = 54; aged 63-81 years; 56% female) who self-administered a single dose (24 international units) of either intranasal OT or a placebo (with identical ingredients as the OT spray but without the synthetic OT; IND 100,860; NCT01823146). The study adopted a randomized, double-blind, between-subject design. The dataset consists of anatomical and functional resting-state neuroimaging scans acquired after nasal spray administration as well as study-specific phenotypic and demographic data. This dataset using both OT administration and neuroimaging is unique in its size and inclusion of both younger and older adults as well as women and men. This data has resulted in published work on OT modulation of cognition, behavior, and neural activation/connectivity. Open access to this data will provide the scientific community with the opportunity to investigate individual differences in the neurocognitive effects of single-dose OT in younger and older adults.

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Single dose intranasal oxytocin administration: Data from healthy younger and older adults

Horta,

Polk,

Ebner

2023

Data in Brief

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Intranasal oxytocin modulates the salience network in aging

Cited by 8 publications

References 154 publications

Intranasal Oxytocin Modulates Decision-Making Depending on Outcome Predictability—A Randomized Within-Subject Controlled Trial in Healthy Males

Intranasal Oxytocin Modulates Decision-Making Depending on Outcome Predictability—A Randomized Within-Subject Controlled Trial in Healthy Males

Single Dose Intranasal Oxytocin Administration: Data from Healthy Younger and Older Adults

Single dose intranasal oxytocin administration: Data from healthy younger and older adults

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