Intranasal selective brain cooling in pigs

Covaciu, Lucian; Allers, Mats; Enblad, Per; Lunderquist, Anders; Wieloch, Tadeusz; Rubertsson, Sten

doi:10.1016/j.resuscitation.2007.07.002

Cited by 45 publications

(28 citation statements)

References 32 publications

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“…The methods differ in that the net measurement time per temperature point is 5 s for phase-mapping and 41 s for MRSI with high spatial definition. However, both methods were able to follow the dynamics of temperature decrease observed with intranasal cooling [12,14]. The measurement of absolute brain temperature is not possible with these techniques.…”

Section: Magnetic Resonance Measurementmentioning

confidence: 99%

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Brain temperature in volunteers subjected to intranasal cooling

et al. 2011

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Section: Magnetic Resonance Measurementmentioning

confidence: 99%

“…An intranasal method for initiating brain cooling where cold saline is circulated within intranasal balloons has previously been successfully applied in pigs [12][13][14]. In the present study, the intranasal balloon catheters circulated with saline at 20°C were applied for 60 min in awake, unsedated volunteers.…”

Section: Introductionmentioning

confidence: 97%

Brain temperature in volunteers subjected to intranasal cooling

et al. 2011

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“…In rat models, flushing the nasopharnyx with cold saline 21 , or cold water passed through tygon tubing have both been attempted 22 . Others have extended these findings to large animal (pig) models 23 . Covaciu and colleagues anesthetized twelve pigs and performed selective cooling via a specially designed thin walled balloon catheter, placed in the nasopharnyx 24 examine the effect of high flow oxygen though the nasopharnyx on brain temperature for 11 intubated adult rats.…”

Section: Non Invasive Techniques Of Coolingmentioning

confidence: 83%

Selective therapeutic hypothermia: A review of invasive and noninvasive techniques

Straus

Prasad

Munoz

2011

Arq. Neuro-Psiquiatr.

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Objective: Therapeutic hypothermia is a promising treatment to prevent secondary neurologic injury. Clinical utility is limited by systemic complications of global hypothermia. Selective brain cooling remains a largely uninvestigated application. We review techniques of inducing selective brain cooling. Method: Literature review. Results: Strategies of inducing selective brain cooling were divided between non-invasive and invasive techniques. Non-invasive techniques were surface cooling and cooling via the upper airway. Invasive cooling methods include transvascular and compartmental (epidural, subdural, subarachnoid and intraventricular) cooling methods to remove heat from the brain. Conclusion: Selective brain cooling may offer the best strategy for achieving hypothermic neuroprotection. Non-invasive strategies have proven disappointing in human trials. There is a paucity of human experiments using invasive methods of selective brain cooling. Further application of invasive cooling strategies is needed. Key words: therapeutic hypothermia, selective brain cooling, neuroprotection, isolated cerebral hypothermia.Hipotermia terapêutica seletiva: uma revisão de técnicas invasivas e não invasivas RESUMO Objetivo: A hipotermia terapêutica é uma estratégia promissora para prevenção do dano neurológico secundário. Sua utilidade clínica é limitada por complicações sistêmicas da hipotermia global. Resfriamento cerebral seletivo (RCS), entretanto, permanece uma técnica pouco estudada. Revisamos aqui as diferentes técnicas de indução de RCS. Método: Revisão de literatura. Resultados: As estratégias de indução de RCS foram divididas em invasivas e não-invasivas. Métodos de remoção de calor do cérebro não-invasivos incluem o resfriamento de superfície e o de vias aéreas superiores; as técnicas invasivas incluem resfriamento transvascular e compartimental (epidural, subdural, subaracnóideo e intraventricular). Conclusão: RCS pode oferecer a melhor estratégia para alcançar neuroproteção hipotérmica. Estratégias não-invasivas têm se mostrado ineficazes em estudos clínicos. Técnicas invasivas foram raramente estudadas em humanos e necessitam ser mais investigadas para tornarem-se úteis. Palavras-Chave: hipotermia terapêutica, resfriamento cerebral seletivo, neuroproteção, hipotermia cerebral isolada.

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“…Experimentally there is some proof that a more immediate and more rapid cooling would be more neuroprotective (Noguchi et al, 2011), but clinically this has not been easy to prove. In spite of this nasal cooling, a method implying a considerably more rapid cooling of the brain has been tried (Castren et al, 2010;Covaciu et al, 2008Covaciu et al, , 2009Weis et al, 2009). Also experimentally mild induced hypothermia has been demonstrated to decrease the ischemia-reperfusion injury on many levels, for example, reduction of extracellular levels of excitatory neurotransmitters; avoidance of proliferation, migration, transformation, and activation of astroglial cells; decrease of p53 protein levels and apoptotic cell death; and mitigating proteins Bcl-2 and cytochrome C and block of proteins responsible for mediating the caspase-independent apoptosis (Gonzalez-Ibarra et al, 2011).…”

Section: Introductionmentioning

confidence: 99%