Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes

Abstract

Maternal exposure to intranasal triamcinolone during pregnancy was not associated with the risk of SGA/spontaneous abortions/overall malformations. However, it has been shown to increase the risk of respiratory system defects. Chance finding cannot be ruled out.

Sleep Pharmacotherapy for Common Sleep Disorders in Pregnancy and Lactation

“…Preferred topical steroids include fluticasone furoate, mometasone, or budesonide. 99 Triamcinolone has been associated with a risk of congenital defects of the respiratory track 100 and is best avoided in pregnancy.…”

Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case–control studies

“…The relevant exposure time window for the analysis of major congenital malformations was the first trimester (organogenesis), which is the critical period in the development of the fetus, associated with most structural defects. 31,32 Although the presence of major congenital malformations is usually noted at birth or in the first year of life, such malformations occur by the end of the first trimester. 33 We stratified exposure to oral fluconazole during each relevant time window as low dose (≤ 150 mg) and high dose (> 150 mg), using the cumulative dose in each period.…”

The safety of intranasal steroids during pregnancy: A good start

“…The data from the unique study of Berard et al 3 are generally reassuring regarding exposure to intranasal corticosteroids and important perinatal outcomes. Notably, previously demonstrated relationships between corticosteroids and oral clefts were not confirmed in this study.…”

“…As a result, some clinicians choose budesonide if starting intranasal glucocorticoids for the first time during pregnancy, although no important differences in efficacy or safety have been demonstrated between the various intranasal glucocorticoid preparations. Not until this issue's article from Berard et al 3 has there been a human study aimed specifically at determining the safety of intranasal corticosteroid use during pregnancy.…”

“…Moreover, large-scale randomized controlled trials to determine drug safety during pregnancy are usually not considered ethical. More large, valid, observational studies with relevant comparison groups, such as the study of Berard et al, 3 are needed so that clinicians can prescribe therapy with the best balance of benefits and risks for their pregnant patients.…”