Intraneural lipoma of the median nerve. Report of two cases and review of the literature

Lipofibromatous Hamartoma of the Median Nerve and its Associated Conditions

“…Lipofibromatous hamartoma of the median nerve is commonly associated with macrodactyly which has been variously described as nerve territory oriented macrodactyly, macro-dystrophia lipomatosa or macrodactylia fibrolipomatosis (Dell, 1985). Other isolated case reports in the literature have documented the association between lipofibromatous hamartoma of the median nerve and ectopic calcification of soft tissues (Amadio et al, 1988;Louis and Dick, 1973;Silverman and Enzinger, 1985), bone exostoses (Friedlander et al, 1969;Silverman and Enzinger, 1985), subcutaneous encapsulated lipomas (Yeoman, 1964) and vascular tumours (Amadio et al, 1988).…”

“…Lipofibromatous hamartoma is a rare, benign neoplasm that usually involves the median nerve (Amadio et al, 1988;Camilleri and Milner, 1998;Declercq et al, 1993;Friedlander et al, 1969;Houpt et al, 1989;Mikhail, 1964;Patel et al, 1979;Pulvertaft, 1964;Rowland, 1967;Rudolph and Jaffe, 1975;Warhold et al, 1993). Involvement of other nerves, such as the radial, ulnar and plantar nerves and the brachial plexus, is extremely rare but has been described (Gouldesbrough and Kinny, 1989;Hauk and Banducci, 1993;Jacob and Buchino, 1986;Paletta and Senay, 1981;Price et al, 1995;Silverman and Enzinger, 1985).…”

Parietal peri-neural lipoma: a case report

“…Symptoms are non-specific depending on the affected nerve including carpal tunnel syndrome or slow-growing painless lump in the wrist or hand in case of lipoma of the median nerve [10] . In our case, the symptoms consisted in a painful parietal growing mass associated with axillary adenopathy.…”

Lipofibromatous hamartoma of the median nerve

“…This association is well addressed in the literature and has prompted speculation that LFH may be associated with neurofibromatosis, though none of the cases reported have a family history of neurofibromatosis [ 3 ]. It is also interesting to note that several cases of LFH have been associated with exostoses and ectopic calcifications [ 20 ]. Gigantism in patients with neurofibromatosis is associated with the development of osteochondromas further seeding this speculation of a possible association.…”