Intraneural reticular perineurioma of the hypoglossal nerve

Abstract

An intraneural reticular perineurioma of the hypoglossal nerve should be included in the differential diagnosis of submandibular swelling.

Cutaneous microcystic/reticular schwannoma: a poorly recognized entity

“…Reticular perineurioma was originally described by Ushigome et al, subsequently designated as retiform perineurioma by Michal, until given its present designation by Graadt van Roggen et al Reticular perineurioma represents a rare subtype of perineurioma showing female predominance, most commonly develops in the fourth and fifth decade of life and displays predilection for distal extremities . Intraneural variants of reticular perineurioma have also been reported . Pathologically, retiform perineurioma features anastomosing spindle‐shaped perineurial cells with fusiform nuclei and characteristic bipolar palely eosinophilic cytoplasm with thin processes, forming a reticular growth pattern .…”

Practical Approach to Histological Diagnosis of Peripheral Nerve Sheath Tumors: An Update

“…Although intraneural perineurioma had been considered as a reactive process (localized hypertrophic neuropathy), the identification of clonal cytogenetic abnormalities involving chromosome 22 as well as the recent discovery of TRAF7 mutations in 60% of cases seems to confirm its neoplastic nature [ 51 , 52 , 53 , 54 , 55 ].…”

Ultrasound of the Hypoglossal Nerve in the Neck: Visualization and Initial Clinical Experience with Patients

“…There are also reports of carotid and vertebral artery dissections leading to hypoglossal nerve injury. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] In a large case series of hypoglossal nerve palsies, the site of the lesion could not be localized in 6%. 9 In the radiologic diagnostic work-up, a segmental imaging approach is advised.…”