Intraneural stimulation for auditory prosthesis: Modiolar trunk and intracranial stimulation sites

Middlebrooks, John C.; Snyder, Russell L.

doi:10.1016/j.heares.2008.04.001

Cited by 45 publications

(50 citation statements)

References 38 publications

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“…5, A and C) is consistent with the fact that cell membrane time constants tend to increase with BF in the CNIC (Geis and Borst 2009). Furthermore, these results resemble a comparable trend observed in the CNIC during electrical stimulation of the AN where higher limiting stimulation rates and shorter latencies were observed for low BF CNIC neurons (Middlebrooks and Snyder 2008).…”

Section: Functional Implicationssupporting

confidence: 85%

Spectral and Temporal Modulation Tradeoff in the Inferior Colliculus

Rodríguez

Read

Escabı́

2010

Journal of Neurophysiology

111

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Rodríguez FA, Read HL, Escabí MA. Spectral and temporal modulation tradeoff in the inferior colliculus. J Neurophysiol 103: 887-903, 2010. First published December 16, 2009 doi:10.1152/jn.00813.2009. The cochlea encodes sounds through frequency-selective channels that exhibit low-pass modulation sensitivity. Unlike the cochlea, neurons in the auditory midbrain are tuned for spectral and temporal modulations found in natural sounds, yet the role of this transformation is not known. We report a distinct tradeoff in modulation sensitivity and tuning that is topographically ordered within the central nucleus of the inferior colliculus (CNIC). Spectrotemporal receptive fields (STRFs) were obtained with 16-channel electrodes inserted orthogonal to the isofrequency lamina. Surprisingly, temporal and spectral characteristics exhibited an opposing relationship along the tonotopic axis. For low best frequencies (BFs), units were selective for fast temporal and broad spectral modulations. A systematic progression was observed toward slower temporal and finer spectral modulation sensitivity at high BF. This tradeoff was strongly reflected in the arrangement of excitation and inhibition and, consequently, in the modulation tuning characteristics. Comparisons with auditory nerve fibers show that these trends oppose the pattern imposed by the peripheral filters. These results suggest that spectrotemporal preferences are reordered within the tonotopic axis of the CNIC. This topographic organization has profound implications for the coding of spectrotemporal features in natural sounds and could underlie a number of perceptual phenomena.

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Section: Functional Implicationssupporting

confidence: 85%

Spectral and Temporal Modulation Tradeoff in the Inferior Colliculus

Rodríguez

Read

Escabı́

2010

Journal of Neurophysiology

111

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“…New electrode designs that can benefit from biological interventions aimed at protecting the SGNs and regenerating their peripheral processes coupled with new stimulation strategies aimed at delivering more focused ES are likely to lead to improvements in cochlear implant performance in the future [59,60]. Moreover, the development of high resolution electrode arrays for direct implantation into the auditory nerve [61] would rely on very good neural survival. Finally, future interventions that combine drug delivery and new electrode designs may be able to take advantage of the re-sprouting capacity of SGN peripheral processes to achieve a more direct interface between the electrode and the nerve to provide high resolution electrical stimulation.…”

Section: Clinical Implications and Future Directionsmentioning

confidence: 99%

Combining Cell-Based Therapies and Neural Prostheses to Promote Neural Survival

et al. 2011

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Cochlear implants provide partial restoration of hearing for profoundly deaf patients by electrically stimulating spiral ganglion neurons (SGNs); however, these neurons gradually degenerate following the onset of deafness. Although the exogenous application of neurotrophins (NTs) can prevent SGN loss, current techniques to administer NTs for long periods of time have limited clinical applicability. We have used encapsulated choroid plexus cells (NTCells; Living Cell Technologies, Auckland, New Zealand) to provide NTs in a clinically viable manner that can be combined with a cochlear implant. Neonatal cats were deafened and unilaterally implanted with NTCells and a cochlear implant. Animals received chronic electrical stimulation (ES) alone, NTs alone, or combined NTs and ES (ES + NT) for a period of as much as 8 months. The opposite ear served as a deafened unimplanted control. Chronic ES alone did not result in increased survival of SGNs or their peripheral processes. NT treatment alone resulted in greater SGN survival restricted to the upper basal cochlear region and an increased density of SGN peripheral processes. Importantly, chronic ES in combination with NTs provided significant SGN survival throughout a wider extent of the cochlea, in addition to an increased peripheral process density. Re-sprouting peripheral processes were observed in the scala media and scala tympani, raising the possibility of direct contact between peripheral processes and a cochlear implant electrode array. We conclude that cell-based therapy is clinically viable and effective in promoting SGN survival for extended durations of cochlear implant use. These findings have important implications for the safe delivery of therapeutic drugs to the cochlea.

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“…The transcochlear approach through the basal cochlear turn described by Simmons [1966] and Badi et al [2002] destroys the cochlear structures and is associated with a high incidence of cerebrospinal fluid leakage from the fundus of the internal auditory canal [Miller and Hillman, 2006]. The middle cranial fossa approach [Assenova et al, 2007] also has its inherent risks of craniotomy, including meningitis and cerebrospinal fluid leakage [Middlebrooks and Snyder, 2008]. Similarly, the posterior fossa approach to the intracranial part of the auditory nerve comprises craniotomy-related risks.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the posterior fossa approach to the intracranial part of the auditory nerve comprises craniotomy-related risks. Moreover, the tonotopic organization within the intracranial portion of the nerve might be more variable than in the modiolar trunk [Middlebrooks and Snyder, 2008]. The infralabyrinthine route opens an access to the internal auditory canal portion of the auditory nerve and preserves the bony labyrinth.…”

Section: Discussionmentioning

confidence: 99%

Navigation-Guided Transmodiolar Approach for Auditory Nerve Implantation via the Middle Ear in Humans

Afifi

Guigou²,

Mazalaigue³

et al. 2015

Audiol Neurotol

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The aim of this study was to assess the surgical feasibility of a transmodiolar approach via the middle ear cavity for an auditory nerve implantation in humans. In the first part of the study, 6 adult human temporal bones underwent a navigator-guided transmodiolar implantation via the middle ear space after a radical mastoidectomy. In the second part, 122 temporal bone CT scans were analyzed for anatomical parametersrelevant to this approach. The nerve implantation was feasible in all temporal bones in laboratory conditions, with a mean target registration error of 0.065 ± 0.0583 mm (n = 6). Evaluation of anatomical parameters on CT scans also supported the feasibility. There was a significant interindividual variation of the modiolar axis and the entry point in relation to visible anatomical landmarks, highlighting the necessity for surgical preplanning.

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Intraneural stimulation for auditory prosthesis: Modiolar trunk and intracranial stimulation sites

Cited by 45 publications

References 38 publications

Spectral and Temporal Modulation Tradeoff in the Inferior Colliculus

Spectral and Temporal Modulation Tradeoff in the Inferior Colliculus

Combining Cell-Based Therapies and Neural Prostheses to Promote Neural Survival

Navigation-Guided Transmodiolar Approach for Auditory Nerve Implantation via the Middle Ear in Humans

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