Intranodal Palisaded Myofibroblastoma; a Case Report and Review of the Literature

Köseoğlu, Reşit Doğan; Özkan, Nilüfer; Filiz, Nurper Onuk; Kayaoğlu, Hüseyin Ayhan; Aydın, Mehtap; Çulha, Emre; Ersoy, Ömer Faik

doi:10.1007/s12253-008-9122-0

Cited by 11 publications

(26 citation statements)

References 19 publications

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“…modified smooth muscle cells comprising the walls of hilar blood vessels 1,7,19 . In addition, the finding that Epstein-Barr virus and herpesvirus-8 have the potential to disrupt myofibroblast proliferation pathways raised suspicion of a viral etiology for the tumor 22,23 , but investigators have failed to unequivocally identify a viral genome 15,24,25 or immunohistochemical evidence of a virus within lesional cells 15,26,27 .…”

Section: Introductionmentioning

confidence: 99%

Intranodal Palisaded Myofibroblastoma

Laskin

Lasota

Fetsch³

et al. 2015

American Journal of Surgical Pathology

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Intranodal palisaded myofibroblastoma is a benign, lymph node-based myofibroblastic tumor of unknown pathogenesis. We report the clinicopathological, immunohistochemical, and genetic molecular features of this rare entity. The study cohort consisted of 14 males and 4 females ranging in age from 31 to 65 (mean, 47; median 49) years with tumors arising in inguinal lymph nodes (n=15), a neck lymph node (n=1), and undesignated lymph nodes (n=2). Most individuals presented with a painless mass or lump. Possible trauma/injury to the inguinal region was documented in four cases. Tumors ranged in size from 1.0 to 4.2 (mean, 3.1; median; 3.0) cm. Microscopically, the process presented as a well-circumscribed, often times pseudoencapsulated nodule (n=17) or nodules (n=1). Tumors consisted of a cellular proliferation of cytologically bland, spindled cells arranged in short fascicles and whorls within a finely collagenous(n=11) or myxocollagenous(n=7) matrix. In 12 tumors, scattered fibromatosis-like fascicles of spindled cells were noted. Histological features characteristic of the process included nuclear palisades (n=16 cases), collagenous bodies (n=15), and perinuclear intracytoplasmic hyaline globules (n=10). Mitotic activity ranged from 0 to 8 (mean,2; median, 1) mitotic figures/50 high-powered fields with no atypical division figures identified. Immunohistochemically, all tumors tested expressed (vimentin (n=3), smooth-muscle actin and/or muscle-specific actin (n=5, each), and nuclear beta-catenin and cyclin D1 (n=8, each). The latter two results prompted a screening for mutations in the beta-catenin gene glycogen synthase kinase-3 beta phosphorylation mutational “hotspot” region in exon 3 using PCR amplification and Sanger sequencing. Single nucleotide substitutions leading to missense mutations at the protein level were identified in 7 of 8 (88%) analyzed tumors and are responsible for the abnormal expression of beta-catenin and cyclin D1. These results demonstrate that mutational activation of the beta-catenin gene is likely a pivotal event in the pathogenesis of intranodal palisaded myofibroblastoma.

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Section: Introductionmentioning

confidence: 99%

Intranodal Palisaded Myofibroblastoma

Laskin

Lasota

Fetsch³

et al. 2015

American Journal of Surgical Pathology

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“…IPM shows both myofibroblastic and smooth muscle differentiation with the formation of the "amianthoid fibres". To date only about 55 cases of IPM have been reported in the English literature [4-6]. In this case report we presented another case of IPM, but originating from retroperitoneum.…”

Section: Introductionmentioning

confidence: 89%

Intranodal palisaded myofibroblastoma originating from retroperitoneum: an unusual origin

2011

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BackgroundIntranodal palisaded myofibroblastoma is one of the primary mesenchymal tumours. The inguinal region is the commonest site of this rare tumour. As there are only about 55 such cases reported in the literature, the precise aetiology and pathogenesis have yet to be explained adequately. Here we report a case of a 72 year old man presented with incidental finding of intranodal palisaded myofibroblastoma in the retroperitoneal region.Case PresentationA 72-year old man presented with abdominal pain in right upper quadrant with an incidental finding of abdominal mass in the right flank. The computerised tomogram scan of abdomen confirmed acute cholecystitis with a 5 x 5 cm retroperitoneal mass. He underwent cholecystectomy with excision of this mass. He recovered well following his operation and was discharged from the hospital. Histological examination confirmed the diagnosis of intranodal palisaded myofibroblastoma.ConclusionTo our knowledge, this is the first case of intranodal palisaded myofibroblastoma originating from retroperitoneum. Along with the rarity of this case, we also discussed its typical histopathological findings, aetiology and pathogenesis.

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“…More than 50 cases have now been described, the majority of which have involved inguinal lymph nodes. The tumour is slightly more common in men and occurs over a wide age range (19–71 years) 3. We report another case and discuss the nature, nomenclature and differential diagnosis of this entity.…”

mentioning

confidence: 84%

“…IPM is a benign tumour with occasional local recurrence reported but no cases that have undergone distant metastasis 3 4. The importance of this tumour lies in its recognition and distinction from other, more aggressive neoplasms.…”

mentioning

confidence: 99%