Intranuclear Inclusions

Inclusion Disease in Childhood

“…In 1932, Rich found similar cells in five cases of whooping cough, but he emphasized that, as only two showed any appreciable infiltration of the bronchial walls, one should guard against considering such a reaction as being caused by a virus. McCordock and Smith (1934) demonstrated typical inclusion cells in the lungs of 18 out of 40 cases of pertussis dying between the ages of a few weeks and 5 years. They also found inclusion cells in the lungs of five children between 3 months and 2 years who at necropsy showed chronic pneumonia with peribronchial infiltration.…”

“…This was first described by Goodpasture and Talbot (1921) who found large numbers of inclusion cells in the inflammatory areas of the lungs, especially within the walls of the chronically inflamed bronchi. Two other cases were mentioned by McCordock and Smith (1934). In none of these were inclusion cells present in the pancreas.…”

“…Typical lesions have been observed in single organs of children dying of a great variety of diseases. Only in the case of neonatal goitre (Pettavel, 1911), and in those cases of whooping cough (McCordock and Smith, 1934, and others), did their presence in the body appear to have been significant.…”

“…While it is possible that this is merely an incidental association, some other explanation is more likely. The condition clinically resembling whooping cough may be a distinct entity caused by the virus; a latent endogenous virus may be activated by infection with the Haemophilus, or the virus may enter the lungs as a secondary invader (McCordock and Smith, 1934). Of equal interest is the finding of inclusion cells in the lungs of children with cystic fibrosis of the pancreas.…”

Significance of Bacteriological Methods in the Diagnosis and Control of Whooping Cough

“…A washed product surely is preferable if significant antigenic properties are not lost. Since we have found the washed live culture capable of giving a typical skin reaction and a vaiccine, even after 3 washings, capable of stimulating Phase I agglutinins rapidly and in high titers, we decided on a washed product.…”