2015
DOI: 10.3390/vetsci2020084
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Intranuclear Inclusions in Renal Tubular Epithelium in Immunodeficient Mice Stain with Antibodies for Bovine Papillomavirus Type 1 L1 Protein

Abstract: The kidneys from six immunodeficient mice examined by Cerberus Sciences and the Animal Resources Centre, displayed karyomegaly with pale eosinophilic, intranuclear inclusions upon histopathological examination. Electron microscopy performed on kidney tissue from 5/6 mice demonstrated margination of the chromatin in large nuclei. Laboratory tests were used to detect nucleic acid of papillomaviruses, polyomaviruses, circoviruses and anelloviruses (4/6 mice), a specific PCR was used to detect murine polyomavirus … Show more

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Cited by 8 publications
(10 citation statements)
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“…Although we do not know how and when MKPV was introduced into our colony, the histopathological features of MKPV-infection, i.e. inclusion body nephropathy, have been described previously in immunocompetent and immunocompromised mice in several facilities in Australia and the USA (Baze et al, 2006; McInnes et al, 2015; Santagostino et al, 2017). A viral etiology was surmised, but not proven (Besselsen et al, 2008).…”
Section: Discussionmentioning
confidence: 93%
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“…Although we do not know how and when MKPV was introduced into our colony, the histopathological features of MKPV-infection, i.e. inclusion body nephropathy, have been described previously in immunocompetent and immunocompromised mice in several facilities in Australia and the USA (Baze et al, 2006; McInnes et al, 2015; Santagostino et al, 2017). A viral etiology was surmised, but not proven (Besselsen et al, 2008).…”
Section: Discussionmentioning
confidence: 93%
“…The occurrence of intranuclear inclusions of undetermined etiology in mouse renal tubular epithelium has been anecdotally reported by veterinary pathologists for over 40 years (Barthold et al, 2016). These inclusions, associated with chromatin margination and karyomegaly, have been reported in both immunocompetent and immunodeficient mice in the USA and Australia (Baze et al, 2006; McInnes et al, 2015). Known mouse pathogens were not detected in affected mice and electron microscopy failed to demonstrate viral particles in the inclusions.…”
Section: Introductionmentioning
confidence: 78%
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“…Large amphophilic intranuclear inclusions causing margination of chromatin and karyomegaly, which closely resemble 1 type of inclusions observed in the present study, have been reported in immunocompetent (ICR), 4 and immunodeficient mice ( scid , NOD scid , and B6.129S7- Rag 1tm1Mom /J). 38 In these cases, TEM showed that the inclusions were composed of electron lucent material of undetermined nature, without evidence of viral particles. Serology, PCR, and IHC were also negative for viruses, with the exception of positive IHC for a bovine papillomavirus antigen in 1 study, a finding of unclear significance.…”
Section: Discussionmentioning
confidence: 93%
“…It has been documented that intranuclear inclusion body nephropathy (IBN) occurs in aging laboratory mice [1]. IBN has been reported predominantly in immunodeficient mice but also in aged immunocompetent mice, including inbred C56BL/6 and outbred Crl:CD1(ICR) mice; however, its aetiology was undetermined until recently [2][3][4][5]. In 2018, Roediger et al reported that IBN in mice was induced by infection with an atypical parvovirus, termed mouse kidney parvovirus (MKPV).…”
Section: Introductionmentioning
confidence: 99%