Intraocular Ciprofloxacin Levels after Oral Administration in Silicone Oil-Filled Eyes

Talwar, Dinesh; Kulkarni, Amol D.; Azad, Rajvardhan; Gupta, Suresh; Velpandian, Thirumurthy; Sharma, Yograj; Rajpal,; Biswas, Nihar Ranjan

doi:10.1167/iovs.02-0499

Cited by 15 publications

(10 citation statements)

References 13 publications

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“…However, 50% of group 2 patients (3/6) had a useful final visual outcome (Fisher's exact test: upper tail P=0. 16, lower tail P=0.03). Thus, while poor outcomes were noted in both the groups, useful visual outcomes were seen following surgery only in group 2 patients.…”

Section: Discussionmentioning

confidence: 92%

“…The attenuated vitreous phase lying adjacent to the inflamed retinal surface, which forms the posterior compartment, is also likely to achieve high antibiotic levels following intravenous administration due to the absence of diffusion into the vitreous cavity. Support for this hypothesis has come in a study carried out by us in which it was shown that antibiotic levels in the retro-silicone oil space after oral administration of ciprofloxacin in two 750-mg doses exceeds the MIC 90 for most bacterial species [16].…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Pars plana vitrectomy with or without silicone oil endotamponade in post-traumatic endophthalmitis

Azad

Keshavamurthy

Talwar

et al. 2003

Graefe's Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Pars plana vitrectomy with or without silicone oil endotamponade in post-traumatic endophthalmitis

Azad

Keshavamurthy

Talwar

et al. 2003

Graefe's Arch Clin Exp Ophthalmol

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“…Moxifloxacin concentrations were determined in each of the samples using a previously described highperformance liquid chromatography technique (HPLC) used for estimation of intraocular ciprofloxacin with slight modifications. 17 Briefly, Thermo Surveyor HPLC (Thermo Electron Corporation, USA) connected with an autosampler, online degasser and photodiode array detector (model 996;Waters) was used. Acetonitrile and phosphate buffer (20 mM) with pH 2.5 (adjusted with phosphoric acid) was used at the ratio of 25 : 75 pumped at the rate of 1 ml/min.…”

Section: Methodsmentioning

confidence: 99%

Vitreous and aqueous penetration of orally administered moxifloxacin in humans

Vedantham

Lalitha

Velpandian

et al. 2006

Eye

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Objective To investigate the intraocular penetration of moxifloxacin into the aqueous and vitreous after oral administration in humans. Methods A prospective, nonrandomized study of 27 consecutive patients scheduled for elective parsplana vitrectomy surgery between 1 October and 31 December 2004 was carried out. Aqueous, vitreous, and serum samples were obtained and analysed after oral administration of a single 400 mg tablet of moxifloxacin a few hours before surgery. Assays were performed using highperformance liquid chromatography. Results Mean7SD moxifloxacin concentrations in the serum (n ¼ 27), aqueous (n ¼ 25), and vitreous (n ¼ 27) were 1.3470.98, 0.2170.21, and 0.0970.09 mg/ml, respectively. The mean7SD sampling times after oral administration of the moxifloxacin tablet for serum, aqueous, and vitreous were 2.0270.51, 1.5370.45, and 1.5570.46 h, respectively. The minimum inhibitory concentration for 90% of isolates (MIC 90 ) was far exceeded in the aqueous for a wide spectrum of key pathogens, whereas it was not exceeded in the vitreous for several organisms. Of note, the MIC 90 for Staphylococcus epidermidis was not exceeded in any of the samples. Conclusions Orally administered moxifloxacin achieves measurable levels in the noninflammed human eye, with the aqueous levels effective against a variety of pathogens. However, the spectrum of coverage does not appropriately encompass the most common causative organisms in endophthalmitis, especially Staphylococcus epidermidis. Further studies are needed to precisely define the role of oral moxifloxacin in the treatment of or prophylaxis against intraocular infections.

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“…The processing was as per our previous publication. 4 (6) Kampougeris et al also mention that the results of our paper have to be interpreted with caution. We too have not claimed so and have mentioned the need for future studies in our paper.…”

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confidence: 68%