“…1,[3][4][5] However, the method has some potential drawbacks, such as a higher incidence of wound leaks, with ensuing incomplete filling with tamponading agents, earlier disappearance and subconjunctival migration of tamponading agents, hypotony, choroidal detachment, retinal detachment, vitreous incarceration, and endophthalmitis. [6][7][8][9][10][11][12][13] Even with recent advances in incision techniques, such as oblique incisions, biplanar cannula insertions, and slit-shaped scleral tunnel incisions, it may be difficult to ensure perfect self-sealing of every entry site, especially in particular cases, such as eyes with myopia or thin sclera, reoperation on a vitrectomized eye, multiple exchanges of instruments, young patients, and extensive vitreous base dissection. 2,3,[12][13][14][15] Furthermore, subclinical leakage occurs even after successful self-sealing on the operating table, and delayed hypotony may develop the next day and last for several days thereafter.…”