Intraocular Hemangiopericytoma

Abstract

A 55-year-old man presented with a smoothly elevated solid choroidal mass with choroidal detachment in the temporal region of the left eye. Both fluorescein and indocyanine green angiography suggested a vascularized lesion such as an angioma. However, radiographic examination revealed a solid, circumscribed, dome-shaped mass. During a 3-month observation, the mass gradually enlarged and invaded the iris. The possibility of malignant melanoma could not be ruled out. Due to rapid and continued growth of the tumor, the eye was enucleated. Histopathologic examination revealed proliferation of spindle-shaped cells surrounding reticulin-positive vessels, which is characteristic of hemangiopericytoma. To our knowledge, this is only the fourth reported case of intraocular hemangiopericytoma and the first diagnosed in a male patient.

Rare Occurrence of an Intraocular Choroidal Solitary Fibrous Tumor/Hemangiopericytoma

“…Including our case with others previously reported, choroidal SFT/HPC tumors occur in a wide age range and with relatively equal frequency in both sexes (3 female and 2 male patients) [14,15,16,17]. In 3 of the cases, patients underwent enucleation, 2 after evidence of local invasion without distant metastasis [14,17] and the other over concern that the lesion represented a malignant melanoma [15].…”

“…In 3 of the cases, patients underwent enucleation, 2 after evidence of local invasion without distant metastasis [14,17] and the other over concern that the lesion represented a malignant melanoma [15]. In one other case, the patient was treated with xenon arc photocoagulation to reduce subretinal fluid, and the tumor remained stationary until her death, 8 years later, from complications of alcoholic cirrhosis [16].…”

“…Intraocular SFT/HPC is rare, with only 4 cases of intraocular tumors diagnosed as either SFT or HPC having been reported in the literature [14,15,16,17]. Herein, we describe the case of a patient with a tumor occurring in the choroid, which was initially favored to be a spindle cell melanoma and was retrospectively identified as an SFT/HPC after the patient had developed delayed and metachronous metastases to the liver and calvarium.…”

Metastatic intraocular hemangiopericytoma in a dog

“…The tumors are reported to be well circumscribed initially with a pseudocapsule covering the mass (Henderson and Farrow, 1978;Sujatha et al, 1994) and attached to deeper structures with freely movable skin over the surface (Caniatti et al, 2001). If the pseudocapsule is breached during surgery or incomplete excision is noted, extensive local regrowth and metastasis can be seen (Shimura et al, 2001). Proper diagnosis of hemangiopericytomas can be challenging from a histopathologic standpoint and recent investigations show that many previous cases diagnosed as such may actually represent one of a spectrum of perivascular wall tumors (Avallone et al, 2007;Palmieri et al, 2013).…”

“…Other reported locations include the lacrimal sac, optic nerve, conjunctiva, and eyelids (Boniuk et al, 1985;Grossniklaus et al, 1986;Sujatha et al, 1994;Charles et al, 1998;Parmar and Rose, 2003;Schwent et al, 2007). There have been only 5 cases of intraocular hemangiopericytoma reported to date (Papale et al, 1983;Gieser et al, 1988;Brown et al, 1991;Toth et al, 1996;Shimura et al, 2001). Of these most were considered primary lesions, however, metastatic spread from another primary location was not completely ruled out.…”