Intraocular <i>Gongylonema</i> Infection: First Case in Humans

Waisberg, Vanessa; Lima, Walter dos Santos; Vasconcelos-Santos, Daniel Vítor

doi:10.1080/09273948.2016.1232739

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…In 2024, in China, a new case of G. pulchrum infection was reported in a patient who raised sheep, thus underlining the authors’ assertions that support the increased risk of contamination in people who live in the vicinity of sheep and cattle farms [ 16 ]. A novel, intraocular localization is described by Waisberg et al [ 57 ], in 2018 in Brazil, in a patient who used to consume unfiltered water.…”

Section: Discussionmentioning

confidence: 99%

First Molecular Data of Gongylonema pulchrum (Rhabditida: Gongylonematidae) in European Fallow Deer Dama dama from Romania

Popovici,

Marin,

Ionescu

et al. 2024

Pathogens

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Due to its adaptive versatility to numerous types of habitats, extremely diverse both in terms of composition and specificity, developed in various areas of the Western Plains of Romania, the European fallow deer (Dama dama) is a species with high ecological plasticity. In this area, the D. dama interacts with other species of wild fauna but also with numerous domestic animals, an important aspect in terms of the sanitary-veterinary status of animal populations, as well as the existence of a potential risk of infection with various species of parasites that can cause the D. dama specimens to obtain certain diseases and even zoonoses. A total of 133 esophagi from D. dama have been examined for helminths. Of the 133 esophagus samples from D. dama, nematodes of the genus Gongylonema were identified in 25 (18.80%). Sequencing revealed that the nematode identified in the samples was 99% similar to the sequence of Gongylonema pulchrum (GenBank no. LC026018.1, LC388754.1, AB646061). The present research is the first report of the nematode G. pulchrum from D. dama in Romania.

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Section: Discussionmentioning

confidence: 99%

First Molecular Data of Gongylonema pulchrum (Rhabditida: Gongylonematidae) in European Fallow Deer Dama dama from Romania

Popovici,

Marin,

Ionescu

et al. 2024

Pathogens

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“…infects several species of mammals and birds (Levine, 1980). In Brazil it has already been found in non-human primates (Oliveira et al, 2019), rodents (Costa Cordeiro et al, 2018), opossums (Quinta˜o e Silva and Costa, 1999), and humans (Waisberg et al, 2018). Human infection, although rare, occurs when intermediate hosts are ingested, in this case, especially beetles and cockroaches of the Blattella Caudell, 1903 genus, which hosts the L3 larva of the parasite.…”

Section: Strongyloides Ransomimentioning

confidence: 99%

Intestinal Parasites in Pecari tajacu and Sus scrofa domesticus in the Caatinga from Southeastern Piauí, Brazil

Sampaio

Sianto

Chame

et al. 2023

Journal of Parasitology

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Tayassuidae Suidae Helminths Infectious diseases Zoonoses ConservationThis study identifies gastrointestinal parasites in the feces of Pecari tajacu (caititu) and Sus scrofa domesticus (domestic pig) in southeastern Piauı´, Brazil. The region covers 2 protected areas, Serra da Capivara National Park and Serra das Confuso˜es National Park, and surrounding communities. Fecal samples from 64 animals, 42 from domestic swine and 22 from caititu, collected between 1985 and 2013, were analyzed by optical microscopy. Helminths and/or protozoa were found in 64% of the domestic pig samples and 27% of the caititu samples, totaling 18 morphospecies:

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“…Human gongylonemiasis, due to Gongylonema pulchrum, occurs on the lips, gums, tongue, and palate eliciting the sensation of a moving worm (s) in the buccal cavity [143]. Removal of the parasite may be curative; however, because of possible additional worms, anthelmintic drugs, including albendazole (400 mg daily for 3 days), have been prescribed [143][144][145][146][147]. However, in a patient having esophageal symptoms, this albendazole regimen failed to prevent recurrence, and a prolonged administration of albendazole (400 mg daily for 30 days) was needed to obtain a complete cure [148].…”

Section: Gongylonemiasismentioning

confidence: 99%

Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update

2021

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The use of albendazole and mebendazole, i.e., benzimidazole broad-spectrum anthelmintics, in treatment of parasitic infections, as well as cancers, is briefly reviewed. These drugs are known to block the microtubule systems of parasites and mammalian cells leading to inhibition of glucose uptake and transport and finally cell death. Eventually they exhibit ovicidal, larvicidal, and vermicidal effects on parasites, and tumoricidal effects on hosts. Albendazole and mebendazole are most frequently prescribed for treatment of intestinal nematode infections (ascariasis, hookworm infections, trichuriasis, strongyloidiasis, and enterobiasis) and can also be used for intestinal tapeworm infections (taeniases and hymenolepiasis). However, these drugs also exhibit considerable therapeutic effects against tissue nematode/cestode infections (visceral, ocular, neural, and cutaneous larva migrans, anisakiasis, trichinosis, hepatic and intestinal capillariasis, angiostrongyliasis, gnathostomiasis, gongylonemiasis, thelaziasis, dracunculiasis, cerebral and subcutaneous cysticercosis, and echinococcosis). Albendazole is also used for treatment of filarial infections (lymphatic filariasis, onchocerciasis, loiasis, mansonellosis, and dirofilariasis) alone or in combination with other drugs, such as ivermectin or diethylcarbamazine. Albendazole was tried even for treatment of trematode (fascioliasis, clonorchiasis, opisthorchiasis, and intestinal fluke infections) and protozoan infections (giardiasis, vaginal trichomoniasis, cryptosporidiosis, and microsporidiosis). These drugs are generally safe with few side effects; however, when they are used for prolonged time (>14-28 days) or even only 1 time, liver toxicity and other side reactions may occur. In hookworms, Trichuris trichiura, possibly Ascaris lumbricoides, Wuchereria bancrofti, and Giardia sp., there are emerging issues of drug resistance. It is of particular note that albendazole and mebendazole have been repositioned as promising anti-cancer drugs. These drugs have been shown to be active in vitro and in vivo (animals) against liver, lung, ovary, prostate, colorectal, breast, head and neck cancers, and melanoma. Two clinical reports for albendazole and 2 case reports for mebendazole have revealed promising effects of these drugs in human patients having variable types of cancers. However, because of the toxicity of albendazole, for example, neutropenia due to myelosuppression, if high doses are used for a prolonged time, mebendazole is currently more popularly used than albendazole in anti-cancer clinical trials.

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Intraocular Gongylonema Infection: First Case in Humans

Cited by 4 publications

References 3 publications

First Molecular Data of Gongylonema pulchrum (Rhabditida: Gongylonematidae) in European Fallow Deer Dama dama from Romania

First Molecular Data of Gongylonema pulchrum (Rhabditida: Gongylonematidae) in European Fallow Deer Dama dama from Romania

Intestinal Parasites in Pecari tajacu and Sus scrofa domesticus in the Caatinga from Southeastern Piauí, Brazil

Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update

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