Intraocular Lymphoma

Melson, Mark R.; Mukai, Sonoyo

doi:10.1097/00004397-200604620-00008

Cited by 3 publications

(7 citation statements)

References 40 publications

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“…Subjective symptoms of patients with intraocular lymphoma include eye pain, red eye, eyelid oedema, blurry vision, floaters, foreign body sensation, photophobia. Some patients may be asymptomatic, and the tumour is detected during random examination [12,13,14]. Objectively we can find infection of the bulbus, cells and precipitates in the anterior chamber, hyphema, hypopyon, iris neovascularisation, vitreous inflammation, vitreous haemorrhage, retinal haemorrhage or exudate, retinitis, oedema of the optic nerve disc, vasculitis, secondary glaucoma.…”

Section: Clinical Manifestationmentioning

confidence: 99%

“…In the beginning, the treatment appears to be successful; the objective finding improves, which is explained by the suppression of reactive lymphocytes, but the effect is only intermittent, and the inflammatory disease subsequently becomes resistant to corticosteroid treatment. In some patients, treatment with systemic immunomodulators such as methotrexate, azathioprine, cyclosporine, cyclophosphamide is carried out, with similar effects as in corticosteroids [13,15].…”

Section: Clinical Manifestationmentioning

confidence: 99%

“…Primary vitreoretinal lymphoma tends to manifest as vitreous inflammatory retinal changes, including changes in the pigment epithelium without anterior segment involvement, although anterior ventricular precipitates and uveitis may rarely occur. Other rare manifestations of vitreoretinal lymphoma, such as vasculitis, hyphema, hypopyon, secondary glaucoma, optic nerve disc oedema, are mentioned above [1,13]. Primary vitreoretinal lymphoma is usually bilateral in 64-83 % of cases, although in the beginning the finding is mostly unilateral.…”

Section: Clinical Manifestationmentioning

confidence: 99%

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Intraocular Lymphoma with Retrobulbar Infiltration. A Case Report

Jurenová¹,

Plesníková²,

Lysková³

et al. 2021

CSO

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Subjective and objective symptoms following intraocular lymphoma could lead to a misdiagnosing at the beginning of disease what is the cause for delay of an effective treatment. The most common manifestation of lymphoma is an inflammatory disease affecting uvea. A multidisciplinary approach to the diagnosis is required. Suspicion based on the ophthalmologic examinations has to be verified by histology. We present a case report of a 78-year-old patient examined at our clinic with progressive loss of vision on the left eye in 6 months, suspected of retinal detachment. Objectively the visual acuity was counting fingers in front of the left eye. Intraocular pressure changed from normotensive into hypertensive values during regular examinations. We realised imaging exams, ultrasonography and magnetic resonance, which proved intraocular tumour with retrobulbar infiltration and retinal detachment. The patient was indicated for enucleation which enabled assignment of a histologic type of intraocular lymphoma B-Non-Hodgkin lymphoma from marginal zone B-cells. We sent the patient to a haematologist-oncologist for managing of the following treatment and we prescribed individual prosthesis to the patient after the enucleation. The patient remains in observation, no surgical treatment, chemotherapy or radiotherapy have been used for 23 months after the enucleation. The enucleation was both a diagnostic and treatment modality.

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Section: Clinical Manifestationmentioning

confidence: 99%

Section: Clinical Manifestationmentioning

confidence: 99%

Section: Clinical Manifestationmentioning

confidence: 99%

See 1 more Smart Citation

Intraocular Lymphoma with Retrobulbar Infiltration. A Case Report

Jurenová¹,

Plesníková²,

Lysková³

et al. 2021

CSO

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“…The list of masquerade syndromes is extensive and includes lymphoid malignancies, ocular melanoma, retinoblastoma, metastatic disease, juvenile xanthogranuloma, retinal degeneration, chronic retinal detachment, trauma, ocular ischaemia, foreign bodies and infection. 2 It is important to consider a wide differential diagnosis particularly when the patient demographic is atypical for standard uveitis, when the clinical phenotype is out of keeping with standard uveitis or when intraocular inflammation is non-responsive to antiinflammatory therapy. However, it is important to bear in mind that vitreoretinal lymphoma and several other masquerade syndromes may respond initially to corticosteroids.…”

Section: Introductionmentioning

confidence: 99%

“…However, it is important to bear in mind that vitreoretinal lymphoma and several other masquerade syndromes may respond initially to corticosteroids. 2,3 The causes of neoplastic and non-neoplastic masquerade syndromes below are by no means exhaustive but the most commonly encountered disease processes are discussed below.…”

Section: Introductionmentioning

confidence: 99%

Uveitis masquerade syndromes: An approach to diagnosis

Lin,

Hall

2023

Clinical Exper Ophthalmology

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Uveitis masquerade syndromes are a diverse group of clinical entities which mimic conventional immune‐mediated uveitis due to the presence of inflammatory signs but are resistant to anti‐inflammatory therapy. Misdiagnosis hinders appropriate management in these conditions and may result in poor outcomes. This review discusses commonly encountered neoplastic and non‐neoplastic disease processes that masquerade as intraocular inflammation with a focus on relevant clinical features and adjunctive investigations that are helpful in reaching a correct diagnosis.

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