Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes

Hoffman, Philip M.; McKelvie, Penny; Hall, Anthony Jh; Stawell, Richard; Santamaria, John

doi:10.1038/sj.eye.6700378

Cited by 138 publications

(105 citation statements)

References 41 publications

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“…Early treatment has been associated with improved survival. 5 Sir, Superior oblique myokymiaFa case report Superior oblique myokymia (SOM) is an unusual, eye movement disorder presenting as episodes of oscillopsia and diplopia.…”

mentioning

confidence: 99%

Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis

Browning

Fraser

2007

Eye

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confidence: 99%

Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis

Browning

Fraser

2007

Eye

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“…Both PCNSL and PIOL may rarely present as T-cell lymphomas. 35,48 In PIOL, malignant lymphoid cells initially invade the retina, vitreous, or optic nerve head, with or without concomitant CNS involvement. 9,36 Primary intraocular lymphoma is a distinct disease entity from primary orbital lymphoma (MALT lymphoma) and from systemic non-Hodgkin lymphomas that usually metastasize to the uveal tissues in the eye and thus are commonly seen in the choroid.…”

Section: Discussionmentioning

confidence: 99%

“…35,52,68 Due to the link to CNS disease, patients with suspected PIOL should receive a thorough medical and neurological examination, neuroimaging of the brain and orbits, and a lumbar puncture. Cerebrospinal fluid should be sent for routine cytological, chemistry, and cytokine analysis.…”

Section: Discussionmentioning

confidence: 99%

Primary Testicular and Intraocular Lymphomas: Two Case Reports and a Review of the Literature

Wallace

Altemare

Shen

et al. 2006

Survey of Ophthalmology

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Testicular lymphoma is a rare neoplasm of the testis that is most commonly seen in older patients. It metastasizes preferentially to extranodal sites, including the skin, central nervous system, Waldeyer ring, contralateral testis, and lung. Two case reports of patients with a history of testicular lymphoma who developed involvement of the vitreous and retina are presented. These are interesting cases as the testis, central nervous system, and eye are all immune privileged organs, which may account for occurrence of disease in these sites. Histopathologic examination of diagnostic vitrectomy specimens from both cases showed atypical lymphoid cells with immunoglobulin heavy chain (IgH) gene rearrangements, consistent with the diagnosis of intraocular B-cell lymphoma. The results of a literature review of all reports of ocular involvement with testicular lymphoma are discussed. Patients with testicular lymphoma are at risk for relapse, particularly in the central nervous system. Clinicians should be suspicious for intraocular lymphoma in patients with a history of testicular lymphoma who present with vitritis or retinal lesions.

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“…29 PIOL usually occurs in adults from the third to the eighth decades of life, 19,27,107 although cases in infants 39,211 and adolescents are documented. 163,183 The mean age of presentation is in the fifth and sixth decades of life.…”

Section: Epidemiologymentioning

confidence: 99%

“…Symptoms at presentation include blurred vision and/or floaters, but visual acuity is usually better preserved than would be expected. 21,37,107,133,213 Anterior segment inflammatory findings are frequently absent, 27 particularly scleral redness or posterior synechiae.…”

Section: Ocular Featuresmentioning

confidence: 99%