Intraocular pressure modifications in patients with acute central/hemicentral retinal vein occlusions

Abstract

Intraocular pressure (IOP) modifications in patients with acute central/hemicentral retinal vein occlusions (RVOs) consist in IOP reductions and increases. The IOP reduction is due to a transitional hyposecretory phase of the aqueous humor, that increases gradually until 3mo after the venous occlusion onset, and then finally disappears after month 4th. The IOP increases lead to the ocular hypertension and glaucoma. The possible pathogenetic correlations between ocular hypertension/glaucoma and acute central/hemicentral RVOs have been classified into three groups: 1) the venous occlusion precedes the ocular hypertension/glaucoma causing neovascular glaucoma and secondary angle-closure glaucoma without rubeosis; 2) the ocular hypertension and the glaucoma precede the venous occlusion and favor its appearance (ocular hypertension, primary angle-closure, primary angle-closure glaucoma, and open angle glaucomas); and 3) the venous occlusion and the ocular hypertension/glaucoma are mostly age dependent appearances due to common vascular and collagen alterations, lacking a causal connection between the 2 conditions.

Causal Association between Glaucoma and Risk of Retinal Vascular Occlusion: A Mendelian Randomization Study

“…Furthermore, this is the rst study to discuss the causal relationship between glaucoma and RVO at the genetic level. Călugăru D et al 11 described the mechanisms involved in the development of RVO in glaucoma patients from a pathohistological perspective. In eyes with narrow angles, intermittent angle closure episodes may trigger the onset of venous occlusion from collapse of the vein, and, as a result, endothelial lesions may lead to intimal proliferation at the level of the lamina cribrosa 26 .…”

“…In eyes with narrow angles, intermittent angle closure episodes may trigger the onset of venous occlusion from collapse of the vein, and, as a result, endothelial lesions may lead to intimal proliferation at the level of the lamina cribrosa 26 . Călugăru M once elaborated three risk factors for central/hemicentral RVO are angle closure 27 ,a permanently high IOP, and glaucomatous cupping of the optic disc 28 . These risk factors can corroborate that glaucoma patients need to be on high alert for RVO.…”

“…A signi cant heterogeneity was detected when all the studies were included (I 2 = 45.6%;p = 0.028) 7 . On the other hand, Călugăru D reported that the venous occlusion and the ocular hypertension/glaucoma are mostly age dependent appearances due to common vascular and collagen alterations, lacking a causal connection between the 2 conditions 11 . Thus, it is important to clarify the causal relationship between glaucoma and RVO.…”

Automatic Diagnosis of Different Types of Retinal Vein Occlusion Based on Fundus Images

“…In this paper, because of the limitations of the dataset, our research objects are all Asians. Tird, because of the diferences of symptoms in diferent situations [47,48], age, gender, family genetic history, and other factors should be considered when building the model to improve the accuracy of the algorithm for diferent categories of RVO. Finally, for the lesion area, the analysis of fundus images with wavelet transforms and the extraction of spectral characteristics of bleeding point areas and edges can further improve efciency [49].…”