“…Therefore, it is important to know some of the purported mechanisms of the unpredictable and sometimes significant IOP elevations associated with endotracheal intubation. 63,177,187 Suggested explanations for IOP elevations with endotracheal intubation are as follows 1, 18,30,88,126,152 : 1) the actual stress of laryngoscopy and the passage of the endotracheal tube through the glottic aperture 30 can cause sympathetic stimulation, which can result in a rise in IOP, 1, 30,187 2) sympathetic stimulation may also affect vasoconstriction and increase central venous pressure, which can therefore increase IOP, 138,178 and 3) adrenergic stimulation may also increase resistance to aqueous humor outflow through the trabecular meshwork, resulting in a rise in IOP. 88 To compensate for potential IOP elevations associated with laryngoscopy and intubation, some studies suggest that the IOP elevation can be minimized with rocuronium, a muscle relaxant, 178 clonidine, 57,94 and dexmedetomidine premedication.…”