Intraoperative Blood Flow Measurements and Liver Allograft Function: Preliminary Results

Gontarczyk, G.; Łągiewska, B; Pacholczyk, Marek; Trzebicki, Janusz; Jureczko, Lidia; Kołacz, Marcin; Kosieradzki, Maciej; Adadyński, L; Wasiak, Dariusz; Rowińskí, W

doi:10.1016/j.transproceed.2005.12.086

Cited by 8 publications

(7 citation statements)

References 5 publications

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“…Interestingly, we observed a marked similarity between the predictive ability of PDRr60 and PDR1 values. PDRr60 values were slightly higher than PDR1 values, probably because of the hyperperfusion status existing at this time 8, 12, 13…”

Section: Discussionmentioning

confidence: 78%

Early noninvasive measurement of the indocyanine green plasma disappearance rate accurately predicts early graft dysfunction and mortality after deceased donor liver transplantation

et al. 2009

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Early diagnosis of graft dysfunction in liver transplantation is essential for taking appropriate action. Indocyanine green clearance is closely related to liver function and can be measured noninvasively by spectrophotometry. The objectives of this study were to prospectively analyze the relationship between the indocyanine green plasma disappearance rate (ICGPDR) and early graft function after liver transplantation and to evaluate the role of ICGPDR in the prediction of severe graft dysfunction (SGD). One hundred seventy-two liver transplants from deceased donors were analyzed. Ten patients had SGD: 6 were retransplanted, and 4 died while waiting for a new graft. The plasma disappearance rate was measured 1 hour (PDRr60) and within the first 24 hours (PDR1) after reperfusion, and it was significantly lower in the SGD group. PDRr60 and PDR1 were excellent predictors of SGD. A threshold PDRr60 value of 10.8%/minute and a PDR1 value of 10%/minute accurately predicted SGD with areas under the receiver operating curve of 0.94 (95% confidence interval, 0.89-0.97) and 0.96 (95% confidence interval, 0.92-0.98), respectively. In addition, survival was significantly lower in patients with PDRr60 values below 10.8%/minute (53%, 47%, and 47% versus 95%, 94%, and 90% at 3, 6, and 12 months, respectively) and with PDR1 values below 10%/minute (62%, 62%, and 62% versus 94%, 92%, and 88%). In conclusion, very early noninvasive measurement of ICGPDR can accurately predict early severe graft dysfunction and mortality after liver transplantation.

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Section: Discussionmentioning

confidence: 78%

Early noninvasive measurement of the indocyanine green plasma disappearance rate accurately predicts early graft dysfunction and mortality after deceased donor liver transplantation

et al. 2009

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“…If a flow meter is unavailable, a Doppler ultrasound of the portal vein can be performed and the waveform analyzed intraoperatively, although this is not as precise as a flow meter. We believe that there are enough data to support the practice that measured portal flows should be obtained and we do so routinely (1,2). If there is significant improvement in portal flow, then the LRV can be ligated at its confluence with the IVC with either a stapler or a ligature.…”

Section: Discussionmentioning

confidence: 96%

“…In orthotopic liver transplantation (LT), adequate portal venous flow is critical for graft survival and function (1–3). Multiple factors can contribute to inadequate portal venous flow.…”

Section: Introductionmentioning

confidence: 99%

Left Renal Vein Ligation: A Technique to Mitigate Low Portal Flow from Splenic Vein Siphon during Liver Transplantation

Slater

Jabbour

Abbass

et al. 2011

American Journal of Transplantation

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“…The intraoperative measurement of the portal venous flow in pediatric patients submitted to liver transplantation can predict which of them are likely to develop portal thrombosis (8) . Additionally, results of preliminary studies suggest that, among several variables, portal flow volume seems to be a good marker for hepatic function (9) . On the other hand, schistosomal portal hypertension has been considered as an ideal model for the study of portal flow physiology (5) .…”

Section: Introductionmentioning

confidence: 99%

“…Despite the wide availability and widespread use of the method, the literature demonstrates controversial results in relation to the Doppler US reproducibility in the measurement of several dopplerfluxometric parameters, among them the flow volume, utilized in the evaluation of the portal vein (9,14) .…”

Section: Introductionmentioning

confidence: 99%

Mensuração do volume de fluxo portal em pacientes esquistossomóticos: avaliação da reprodutibilidade do ultra-som Doppler

et al. 2008

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OBJETIVO: Avaliar a reprodutibilidade do ultra-som Doppler na quantificação do volume de fluxo portal em pacientes esquistossomóticos. MATERIAIS E MÉTODOS: Estudo prospectivo, transversal, observacional e autopareado, avaliando 21 pacientes portadores de esquistossomose hepatoesplênica, submetidos a mensuração do fluxo portal pelo ultra-som Doppler por três observadores, de forma independente, sendo calculada a concordância entre estes, dois a dois, pelo coeficiente de correlação intraclasse, teste t-pareado e grau de linearidade de Pearson. RESULTADOS: A concordância interobservador foi excelente. O coeficiente de correlação intraclasse variou entre 80,6% e 93,0% (IC a 95% [65,3% ; 95,8%]), com coeficiente de correlação de Pearson variando entre 81,6% e 92,7% e sem diferença estatisticamente significante entre os observadores quanto à média do fluxo portal mensurado pelo ultra-som Doppler (p = 0,954 / 0,758 / 0,749). CONCLUSÃO: O ultra-som Doppler é um método confiável para quantificar o fluxo portal em pacientes portadores de hipertensão porta de origem esquistossomótica, apresentando boa concordância interobservador.

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Intraoperative Blood Flow Measurements and Liver Allograft Function: Preliminary Results

Cited by 8 publications

References 5 publications

Early noninvasive measurement of the indocyanine green plasma disappearance rate accurately predicts early graft dysfunction and mortality after deceased donor liver transplantation

Early noninvasive measurement of the indocyanine green plasma disappearance rate accurately predicts early graft dysfunction and mortality after deceased donor liver transplantation

Left Renal Vein Ligation: A Technique to Mitigate Low Portal Flow from Splenic Vein Siphon during Liver Transplantation

Mensuração do volume de fluxo portal em pacientes esquistossomóticos: avaliação da reprodutibilidade do ultra-som Doppler

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