Intraoperative changes in the pericardium: a study via electron microscope

Yener, Ali Galip

doi:10.5606/tgkdc.dergisi.2011.090

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Post-operative adhesion formation is a common and serious problem in ENT and other fields of surgery. For instance, intestinal adhesions can cause severe manifestations, such as ileus; in obstetrics and gynaecology, ovarian or intra-tubal adhesions lead to infertility and ectopic pregnancies, while in cardiovascular surgery, pericardial damage can lead to potentially fatal tamponade secondary to post-operative adhesions 1 . Inflammation occurring due to mucosal trauma in the middle ear can result in the formation of post-operative adhesions and related complications, such as ossicular fixation, retraction of graft and residual tympanic membrane.…”

Section: Introductionmentioning

confidence: 99%

Histological analysis of the effects of anti-adhesive haemostatic agents on the middle ear of the guinea pig

Kulduk

Eren

et al. 2014

J. Laryngol. Otol.

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Section: Introductionmentioning

confidence: 99%

Histological analysis of the effects of anti-adhesive haemostatic agents on the middle ear of the guinea pig

Kulduk

Eren

et al. 2014

J. Laryngol. Otol.

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“…Mesothelial cells play a key role in adhesion progression and recovery. [2] Following tissue damage, the mesothelium releases a fibrinogen-rich exudate that includes chemical and inflammatory mediators, and the conversion of fibrinogen to fibrin through these mediators leads to fibrous adhesions. In addition, it has been reported that fibrinolytic activity is significantly decreased in injured mesothelial cells.…”

mentioning

confidence: 99%

“…In addition, it has been reported that fibrinolytic activity is significantly decreased in injured mesothelial cells. [2][3][4] Mesothelial cell migration from undamaged areas occurs in the first 48 hours, and mesothelial recovery is completed within seven days. [4] Therefore, methods implemented to prevent adhesion formation have focused on decreasing the inflammatory response, inhibiting the coagulation system, and activating the fibrinolytic system through pharmacological agents or separating adhesive surfaces from each other by using physical barriers during the recovery process.…”

mentioning

confidence: 99%

Evaluation of polylactide film for prevention of pericardial adhesion in a rabbit model

Gürbüz¹

2015

Turk Gogus Kalp Dama

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Bu çalışmada pelvik yapışıklıkları önlemede etkinliği kanıtlanmış biyoemilebilir polilaktid bariyerin ameliyat sonrası perikardiyal yapışıklıkları önlemedeki etkinliği bir hayvan modelinde değerlendirildi. Ça lış ma pla nı: Kırk Yeni Zelanda beyaz tavşanı eşit olarak kontrol ve tedavi gruplarına ayrıldı. Deneklere sol anterior torakotomi ve parsiyel perikardiyektomi sonrası epikardiyal abrazyon uygulandı. Kontrol gruplarında (grup 1 ve 2) retrosternal yapışıklıklara izin vermek için perikard açık bırakıldı. Tedavi gruplarında ise (grup 3 ve 4) perikardiyal defekt 0.02 mm biyoemilebilir polilaktid bariyer ile kapatıldı. Ameliyat sonrası makroskopik ve mikroskopik değerlendirmeler gruplar hakkında bilgisi olmayan değerlendirmeciler tarafından grup 1 ve 3'te üçüncü haftanın sonunda, grup 2 ve 4'te ise altıncı haftanın sonunda yapıldı. Bul gu lar: Makroskopik ve histopatolojik değerlendirmeler kontrol ve tedavi grupları arasında adezyon gelişimi açısından anlamlı farklılık olmadığını gösterdi. Ancak polilaktid bariyer tedavi gruplarında mezotelyum benzeri hücre tabakasının gelişimini destekledi. So nuç: Polilaktid bariyer mezotel hücre tabakasının rejenerasyonuna yardımcı olsa da perikardiyal yapışıklıkların gelişimini önlememektedir. Anah tar söz cük ler: Biyoemilebilir polilaktid bariyer; kalp cerrahisi; perikardiyal yapışıklıklar.

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Investigation of the antiangiogenic behaviors of rivaroxaban and low molecular weight heparins

Yavuz

Çalışkan

Karahan

et al. 2014

Blood Coagulation &Amp; Fibrinolysis

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Antithrombotic agents play important roles in the prophylactic and therapeutic management of many cardiovascular disorders. Therefore, many researchers have focused on developing new strategies for anticoagulation. New oral anticoagulants and factor Xa inhibitors are products of such research. Although they are identified as advantageous, there are limited data available about their multisystemic interactions. Thus, the antiangiogenic behaviors of oral factor Xa inhibitors and low molecular weight heparins (LMWHs) were investigated in this study. The chick chorioallantoic membrane (CAM) model was designed to investigate the antiangiogenic potential of new oral factor Xa inhibitors (rivaroxaban) and LMWHs (enoxaparin sodium and tinzaparin sodium). Four different molar concentrations (10, 10, 10, and 10 μmol/l) were studied for each drug. Each concentration was studied on 20 fertilized eggs. Vessel structures were evaluated under a stereoscopic microscope, and vessel formation was scaled according to previous literature. Both enoxaparin and tinzaparin sodium have increased antiangiogenic efficacy on CAM in a dose-dependent manner. However, this increased efficacy did not reach significant levels (average score < 0.5). On the contrary, while rivaroxaban showed dose-dependent antiangiogenic properties similar to enoxaparin and tinzaparin, a significant average antiangiogenic score (0.7) was detected at 10 μmol/l concentrations. New oral anticoagulants seem to be more favorable. However, their safety for the cardiovascular system needs to be clarified through microsystem studies on, for example, angiogenesis.

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Intraoperative changes in the pericardium: a study via electron microscope

Cited by 3 publications

References 12 publications

Histological analysis of the effects of anti-adhesive haemostatic agents on the middle ear of the guinea pig

Histological analysis of the effects of anti-adhesive haemostatic agents on the middle ear of the guinea pig

Evaluation of polylactide film for prevention of pericardial adhesion in a rabbit model

Investigation of the antiangiogenic behaviors of rivaroxaban and low molecular weight heparins

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