Intraoperative Chemotherapie zur Bestimmung unterschiedlicher Cytotoxizität von 5-FU im Lebermetastasengewebe von Patienten mittels 19-F-Hochfeld MR-Spektroskopie

Assignment and pH dependence of the19F-NMR resonances from the fluorouracil anabolites involved in fluoropyrimidine chemotherapy

“…[13][14][15][16][17][18][19][20][21][22] Similar resolution is obtained with perfused organs 23 or intact cell cultures. [24][25][26][27][28][29] Further resolution of F-Nucsd and F-Nuctd signals into individual components can be achieved only at very high field strengths, to some extent in intact tissue samples, [30][31][32] but most readily in extracts. 23,[33][34][35][36][37] Biofluids such as plasma and urine yield high-resolution spectra but generally contain only fluoropyrimidine catabolites and their by-products and do not provide information about the cytotoxic anabolites which are of interest in chemotherapy.…”