Intraoperative Daunorubicin Versus Conjunctival Autograft in Primary Pterygium Surgery

Abstract

We conclude that intraoperative daunorubicin (0.02%) and conjunctival autograft are both equally effective adjuncts to pterygium surgery.

Evaluation of efficacy and safety of daunorubicin in glaucoma filtering surgery

“…6 Although the antifibroblastic action of DNR has been known for over two decades, its safety in various ophthalmic surgeries has been demonstrated in the last decade. DNR has increasingly been used to improve the success rate of ocular surgeries, including strabismus surgery, 7 pterygium surgery, 8 retinal detachment surgery, 9 and in the prevention of PCO following cataract extraction. 10,11 Dadeya et al 16,6 evaluated the safety and efficacy of intraoperative 0.02% DNR in strabismus surgery and pterygium surgery.…”

“…Daunorubicin (DNR) is a glycosidic antimetabolite that inhibits fibroblast proliferation in vitro and in vivo. 6 The antifibroblastic action of DNR has been used both in animal studies and in human subjects to improve the success rate of various ophthalmic surgeries, including strabismus surgery, 7 pterygium surgery, 8 and retinal detachment surgery, 9 and in the prevention of posterior capsular opacification (PCO) following cataract extraction. 10,11 In glaucoma, DNR has been used experimentally and in human subjects to improve the success rate of high-risk GFS by way of a biodegradable slow-release subconjunctival (s/c) implant, as preoperative and postoperative s/c injections following trabeculectomy.…”

Comparative study of intraoperative application of daunorubicin and conjunctival autograft in primary pterygium surgery: an interesting followup study

“…In their study, they found complications like pyogenic granuloma in 5.5%, graft oedema in 2.77% loose graft in 2.77 % and dellen formation in 2.77%. 21 In group2 patients three (10%) patients developed chemosis and four (13.3%) patient had delayed epithelialisation.…”

“…In his study minor complications like conjunctival graft oedema, Pyogenic granuloma, epithelial inclusion cyst formation, retraction and necrosis of graft was present, 14 which almost matches with my study. Dadeya et al (2002) conducted a study on conjunctival autograft. In their study, they found complications like pyogenic granuloma in 5.5%, graft oedema in 2.77% loose graft in 2.77 % and dellen formation in 2.77%.…”

“…20 A comparative study of intra-operative daunorubicin and conjunctival autograft in pterygium surgery was done by dadeya et al (2002). 21 In their study, group A patients underwent bare sclera excision along with conjunctival autograft and group B patients underwent bare sclera excision with intra-operative daunorubicin (0.02%) for 3 minutes. They found recurrence rates of 8.33% in group A and 7.14 % in group B (21) in present study, when recurrence rates of the two groups were compared statistically, the difference was not significant.…”