2013
DOI: 10.1002/mds.25691
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Intraoperative dopamine release during globus pallidus internus stimulation in Parkinson's disease

Abstract: These findings suggest that additional mechanisms not directly dependent on pallidal DA release may be involved in the clinical effects of HFS of the globus pallidus internus.

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Cited by 21 publications
(20 citation statements)
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“…In the last decades microdialysis in the human brain has allowed us to study neurotransmitters in different conditions, for example in PD. In 1990 the first study using stereotaxy in combination with microdialysis in human was published (169) and after that several studies have shown that microdialysis is a feasible method for studying neurotransmitter levels in the BG in human (130,(170)(171)(172).…”
Section: Areas Of Applicationmentioning
confidence: 99%
“…In the last decades microdialysis in the human brain has allowed us to study neurotransmitters in different conditions, for example in PD. In 1990 the first study using stereotaxy in combination with microdialysis in human was published (169) and after that several studies have shown that microdialysis is a feasible method for studying neurotransmitter levels in the BG in human (130,(170)(171)(172).…”
Section: Areas Of Applicationmentioning
confidence: 99%
“…Kehr (2007) emphasizes the importance of a small exposed surface. Overall, human studies have been conducted with membranes that are 2-3 mm long (31,46) To improve stability, the very far tip of the membrane is usually covered with glue and not meant to be perfused (28,33). For DBS targeting structures, such as the subthalamic nucleus and globus pallidus, membranes that are 2-3 mm long are ideal due to size of these nuclei.…”
Section: Probe Designmentioning
confidence: 99%
“…In-situ MRI allowed registration of the whole histological brain to its own scan before the occurrence of tissue processing deformations, and normalization to MNI space. As such, this high-resolution and highcontrast histological atlas could be directly used in both populational studies 14 or to map individual patient's anatomy [15][16][17] . This methodology improves the visualization and assists volumetric reconstruction of complex anatomical structures and fiber tracts.…”
Section: Introductionmentioning
confidence: 99%