Intraoperative frozen section is essential for assessment of myometrial invasion but not for histologic grade confirmation in endometrial cancer: a ten-year experience

Abstract

Evaluation of the histologic grade by EB and of the depth of myometrial invasion by intraoperative biopsy is a good option for deciding the necessity of lymphadenectomy.

Intraoperative Gross Examination and Intraoperative Frozen Section in Patients With Endometrial Cancer for Detecting Deep Myometrial Invasion

“…Approximately 6% to 17% of preoperative grades 1 and 2 tumors are grade 3 on final diagnosis. 16,22,23,25,32 Additionally, a crucial question is who performs the IGE. It needs to be a person trained in gross pathology.…”

Sentinel lymph node mapping with pathologic ultrastaging: A valuable tool for assessing nodal metastasis in low-grade endometrial cancer with superficial myoinvasion

“…Intraoperative frozen section to determine grade, depth of myometrial invasion (DMI), LVI, and tumor size is not routinely performed at our institution, as pelvic lymph nodes are routinely assessed using our SLN mapping protocol. Thus, final pathologic assessment of myometrial invasion was used as a substitute for intraoperative DMI evaluation as other studies have reported high correlation between intraoperative assessment of DMI to final DMI [23,24]. We excluded any patients with a final DMI ≥50%.…”

Cancer of the corpus uteri

“…The most accurate means of assessing both depth of myometrial invasion and cervical involvement is MRI scanning and intraoperative frozen section [15–17]. CT and MRI are equivalent in terms of evaluating nodal metastases, but neither is good enough to replace surgical lymph node assessment, which provides histological confirmation [18,19].…”