Intraoperative High-Dose Rate of Radioactive Phosphorus 32 Brachytherapy for Diffuse Recalcitrant Conjunctival Neoplasms

Marr, Brian P.; Abramson, David H.; Cohen, Gilad; Williamson, Matthew J.; McCormick, Beryl; Barker, Christopher A.

doi:10.1001/jamaophthalmol.2014.5079

Cited by 12 publications

(5 citation statements)

References 18 publications

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“…[82] A phosphorus-32 impregnated film was applied to patients with recurrent or residual tumors, delivering a median dose of 15 Gy in one fraction at 1 mm. Marr et al reported 75% recurrence-free survival.…”

Section: Treatmentmentioning

confidence: 99%

Advances in the management of conjunctival melanoma

Vora

Demirci

Marr

et al. 2017

Survey of Ophthalmology

102

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Section: Treatmentmentioning

confidence: 99%

Advances in the management of conjunctival melanoma

Vora

Demirci

Marr

et al. 2017

Survey of Ophthalmology

102

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“…Brachytherapy is another commonly applied therapy in the management of this group of patients. There is a body of literature on favorable results with the use of isotopes either as plates, such as strontium, phosphorus, and iodine [ 24 , 25 , 26 ], or isotopes coupled to an (anti-CD20) antibody [ 27 ]. A favorable experience shared by Regueiro et al .…”

Section: Discussionmentioning

confidence: 99%

Single-fraction low-energy electronic brachytherapy for conjunctival lymphoma

Cabrera

Buitrago

Fuentes

et al. 2020

jcb

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Purpose Conjunctival lymphoma represents an uncommon tumor, accounting for 5-10% of total extranodal lymphomas. Although radiotherapy is a frequent treatment option, limited capacities and lack of specialized centers are common problems in Peru, forcing radiation oncologists to apply short courses of radiotherapy. Here, we report a case series of patients treated with a novel single-shot scheme. Additionally, we present a literature review of the current short-course irradiation strategies. Cases presentation Three cases of conjunctival marginal zone (B-cell) lymphoma (marginal zone lymphoma [MZL]/mucosa-associated lymphoid tissue [MALT]) of the fornix are presented. Following biopsy and sonographic assessment of the lesion thickness, we applied a focused single dose of 14 Gy kilovoltage brachytherapy (prescribed to the maximum thickness of the lesion). Follow-up was scheduled in quarterly intervals. After 28, 31, and 40 months of follow-up, none of the three patients treated exhibited acute or chronic toxicities and remained local or distant disease-free. Conclusions Single dose kilovoltage brachytherapy was effective and safe in this small cohort of patients. Based on the literature, there is an evidence that local treatment in short-course radiotherapy is effective and should be considered amongst therapeutic options for these patients; however, this novel approach should be evaluated prospectively in a larger cohort.

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“…They delivered a median dose of 15 Gy to six patients with recurrent or residual disease after primary treatments for SCC, sebaceous carcinoma or lymphoma. At 24 months follow-up, they reported a recurrence free survival rate of 75%, improvement in visual acuity in 5 of the 6 patients, and only 1 severe adverse event of corneal ulcer and perforation [ 17 ].…”

Section: Homogenous Studiesmentioning

confidence: 99%

“…Notable late toxicities reported included stenosis or stricture in 1.6%–4.7% [ 8 , 14 , 16 ], infection in 0.8%–16.7% [ 14 , 17 , 47 , 59 ], xerostomia in 0.8%–9.3% [ 8 , 14 , 47 ], dysphagia in 26% [ 13 ], osteoradionecrosis in 1.6%–17.4% [ 14 , 21 , 32 ] and carotid artery rupture in 2.3%–3.6% [ 32 , 36 , 57 ].…”

Section: Heterogenous Studiesmentioning

confidence: 99%

Systematic review of intraoperative radiation therapy for head and neck cancer

Villafuerte¹,

Ylanan²,

Wong³

et al. 2022

ecancer

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Multidisciplinary treatments with surgery, radiation therapy, and chemotherapy are the cornerstones in the management of locally advanced head and neck malignancies. In most cases, radiation is delivered via external beam radiation therapy (EBRT). Intraoperative radiation therapy (IORT), on the other hand, is the delivery of precise doses of radiation to selected target volumes within the exposed surgical field while at the operating room. Most studies on its use on head and neck cancers are limited to single-institutional retrospective case series. We performed a systematic review to consolidate the existing literature on IORT for head and neck malignancies. Fifty-two studies representing a mixed population of 2,389 patients were included in this review. IORT via electrons (intraoperative electron radiation therapy), brachytherapy (intraoperative high dose-rate brachytherapy) or photons was administered in numerous settings, but most commonly as part of a reirradiation regimen following salvage surgery for recurrent tumours. Often, additional EBRT was also planned postoperatively. This review illustrates that IORT is a promising treatment modality in head and neck cancer. Multiple single-institutional studies spanning several decades have demonstrated benefit in terms of local control with reasonable toxicity. However, randomised trials comparing it with current standards of care are still needed.

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Intraoperative High-Dose Rate of Radioactive Phosphorus 32 Brachytherapy for Diffuse Recalcitrant Conjunctival Neoplasms

Cited by 12 publications

References 18 publications

Advances in the management of conjunctival melanoma

Advances in the management of conjunctival melanoma

Single-fraction low-energy electronic brachytherapy for conjunctival lymphoma

Systematic review of intraoperative radiation therapy for head and neck cancer

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