Intraoperative identification of a neuro endocrine tumour diagnosed by 68Ga-DOTATOC PET but undetectable by surgical palpation or conventional imaging

Freesmeyer, Martin; Wurst, Ch.; Uberrueck, T.; Scholz, Th.; Knösel, Th.; Schulz, Stefan; Settmacher, Utz

doi:10.1055/s-0037-1621114

Cited by 11 publications

(12 citation statements)

References 7 publications

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“…The intraoperative exertion of a gamma probe often results in the extension of the planned surgical procedure, especially in an extended lymph node resection. It permits the identification of previously occult metastases and the localization of hidden lymphatic lesions [ 8 , 9 ] . Although little is known about development of second NETs in patients without multiple endocrine neoplasia syndromes, follow-up of patients with NETs using SSTR-PET/CT will help in the detection of tumor recurrence or other non-related NETs [ 10 ] .…”

Section: Discussionmentioning

confidence: 99%

Concomitant lung and gastroenteropancreatic neuroendocrine tumors and the value of gallium-68 PET/CT

Kaemmerer

Khatib-Chahidi²,

Baüm³

et al. 2011

Cancer Imaging

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Well-differentiated neuroendocrine tumors (NETs) of the lung occur as typical and atypical carcinoids. Little is known about the biology of these tumors in respect of their ability to metastasize or the probability of development of concomitant neuroendocrine tumors. Here we report a patient diagnosed with a second neuroendocrine tumor of the ileum 4 years after curative resection of a typical carcinoid of the left lung. The intestinal neuroendocrine tumor was successfully detected by gallium-68 based somatostatin receptor positron emission tomography (PET)/computed tomography (CT) and surgically removed using gamma probe detection based on the same labeling. This case report underlines the utility of somatostatin receptor PET/CT based detection and follow-up of NETs.

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Section: Discussionmentioning

confidence: 99%

Concomitant lung and gastroenteropancreatic neuroendocrine tumors and the value of gallium-68 PET/CT

Kaemmerer

Khatib-Chahidi²,

Baüm³

et al. 2011

Cancer Imaging

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“…This also results in a substantially enlarged diameter of the end products: typically a probe-head diameter between 25-35 mm [124,125]. This also negatively influences the weight, where a high-energy γ probe is generally much heavier than a low-to-mid energy γ probe [126][127][128][129]. Therefore, both probe diameter and weight restrict the intraoperative utility of such probes [130].…”

Section: High-energy Gamma (γ) Probes (>400 Kev)mentioning

confidence: 99%

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

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Introduction: Radioguided surgery is an ever-evolving part of nuclear medicine. In fact, this nuclear medicine sub-discipline actively bridges non-invasive molecular imaging with surgical care. Next to relying on the availability of radio-and bimodal-tracers, the success of radioguided surgery is for a large part dependent on the imaging modalities and imaging concepts available for the surgical setting. With this review, we have aimed to provide a comprehensive update of the most recent advances in the field. Areas covered: We have made an attempt to cover all aspects of radioguided surgery: 1) the use of radioisotopes that emit γ, β + , and/or β − radiation, 2) hardware developments ranging from probes to 2D cameras and even the use of advanced 3D interventional imaging solutions, and 3) multiplexing solutions such as dual-isotope detection or combined radionuclear and optical detection. Expert opinion: Technical refinements in the field of radioguided surgery should continue to focus on supporting its implementation in the increasingly complex minimally invasive surgical setting, e.g. by accommodating robot-assisted laparoscopic surgery. In addition, hybrid concepts that integrate the use of radioisotopes with other image-guided surgery modalities such as fluorescence or ultrasound are likely to expand in the future.

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“…30 The feasibility and efficacy of using an electronically collimated high-energy probe during surgery has also been proven in our study. 18 This study showed that gamma probeguided surgery leads to a change in the management in 56% of patients. Visually, it was not possible to differentiate the pathologically enlarged, tumor infiltrated lymph nodes from the nonpathologically enlarged/inflammatory lymph nodes.…”

Section: Discussionmentioning

confidence: 97%

“…One of the additional advantages using electronic collimation is the possibility to provide suppression of background, in forward direction which is mandatory and unique for RGS using positron emitters. 15,18,38 …”

Section: Discussionmentioning

confidence: 99%

“…Only some case reports have been already published. 18 The successful use of radioguided surgery (RGS) in other surgical procedures eg, sentinel lymph node detection, thyroid cancer, and parathyroid adenoma localization prompted us to use RGS in NET. The aim of this prospective study was (a) to test the feasibility of doing RGS using short-lived positron emitters like gallium-68 labeled with SMS-R analogs, (b) to determine the lesion-based sensitivity of RGS in comparison to previous PET/CT and surgical palpation in the intraoperative detection of NET, and (c) to evaluate the impact of the planned operation procedure.…”

mentioning

confidence: 99%

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Radioguided Surgery in Neuroendocrine Tumors Using Ga-68-Labeled Somatostatin Analogs

Kaemmerer

Prasad²,

Daffner³

et al. 2012

Clinical Nuclear Medicine

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Intraoperative identification of a neuro endocrine tumour diagnosed by 68Ga-DOTATOC PET but undetectable by surgical palpation or conventional imaging

Cited by 11 publications

References 7 publications

Concomitant lung and gastroenteropancreatic neuroendocrine tumors and the value of gallium-68 PET/CT

Concomitant lung and gastroenteropancreatic neuroendocrine tumors and the value of gallium-68 PET/CT

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Radioguided Surgery in Neuroendocrine Tumors Using Ga-68-Labeled Somatostatin Analogs

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