Intraoperative Imprint Cytologic Evaluation of Sentinel Lymph Nodes for Lobular Carcinoma of the Breast

Creager, Andrew J.; Geisinger, Kim R.; Perrier, Nancy D.; Shen, Perry; Shaw, Jo Ann; Young, Peter R.; Case, Doug; Levine, Edward A.

doi:10.1097/01.sla.0000103072.34708.e3

Cited by 78 publications

(73 citation statements)

References 43 publications

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“…In contrast, the sensitivity of IIC N in the detection of lymph node metastases in patients with lobular carcinoma was only 38.7% (Tables 6, 7). Nonetheless, despite the finding that ILC metastases are more difficult to detect compared with metastases from other breast tumor types, 14 ILC metastases were identified by IIC N in 24 of 62 cases (38.7%) in the current study, thus eliminating the need for a second surgical procedure. In contrast to the findings reported by Creager et al, 14 the difference in IIC N sensitivity between IDC and ILC proved to be statistically significant in the current study (chi-square test: P ϭ 0.012).…”

Section: Discussionmentioning

confidence: 89%

Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma

Cox

Centeno

Dickson

et al. 2004

Cancer

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Section: Discussionmentioning

confidence: 89%

Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma

Cox

Centeno

Dickson

et al. 2004

Cancer

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Section: Discussionmentioning

confidence: 99%

“…25,26 Both of these studies concluded that the sensitivity of TIC was better for detecting macrometastases than micrometastasis. 25,26 A small study of 17 patients demonstrated that TIC was accurate in patients who had received preoperative chemotherapy. 27 Importantly, this study identified distinct TIC cytologic patterns in those patients treated with preoperative chemotherapy, which may confound accurate slide interpretation in this patient subgroup.…”

Section: Discussionmentioning

confidence: 99%

Is intraoperative touch imprint cytology of sentinel lymph nodes in patients with breast cancer cost effective?

Jeruss¹,

Hunt²,

Xing³

et al. 2006

Cancer

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BACKGROUND.Sentinel lymph nodes (SLNs) are generally evaluated postoperatively, requiring 5–7 days for assessment. SLNs can also be evaluated intraoperatively by using touch imprint cytology (TIC), thus providing the surgeon immediate feedback and allowing for concurrent completion node dissection (CND) for positive SLNs. The authors hypothesized that TIC, when compared with standard postoperative SLN assessment alone, would permit a cost‐effective evaluation of SLNs in patients with clinically node‐negative breast cancer.METHODS.A decision‐analysis model was created to compare TIC with standard postoperative SLN assessment alone. Sensitivity and specificity of TIC were determined prospectively from 342 patients who underwent SLN biopsy assessed by both techniques. Short‐term health states associated with surgical staging were defined, and utilities were estimated using EuroQol‐5D. Base‐case analysis was performed to estimate quality‐adjusted life years and the incremental cost‐effectiveness ratio. Sensitivity analyses were performed to examine stability of model parameters.RESULTS.For each tumor stage, TIC was cost effective, and for patients with larger tumors (T3 and T4), TIC was the dominant strategy. The analysis was robust to changes in sensitivity and specificity of TIC, prevalence of metastasis, probability of complications, and cost. However, when utility associated with standard SLN assessment was 0.9 or greater, this became the preferred strategy.CONCLUSIONS.TIC is cost effective for assessing SLN metastasis intraoperatively. For patients with larger tumors, it is not only more effective, but also less costly than standard SLN assessment alone. TIC may be particularly useful for patients who experience significant anxiety while awaiting results of standard SLN assessment. Cancer 2006. © 2006 American Cancer Society.

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“…Furthermore, tissue fixation and, to a lesser degree, tissue processing, are potential causes of variation in the reproducibility of immunohistochemical staining [28]. Above and beyond that, in cytologic preparations, the cells are whole, a larger surface of the tumor is sampled, and tissue is preserved for subsequent pathological and molecular analyses [27,[29][30][31]. It is now firmly established that a wide variety of markers can be applied on cytologic preparations and that immunocytochemistry correlates well with immunohistochemistry [32][33][34][35][36].…”

Section: Methodsmentioning

confidence: 99%

The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma

Athanassiadou¹,

Patsouris²,

Tsipis³

et al. 2011

Folia Histochem Cytobiol.

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Abstract:To investigate the prognostic significance of Survivin and Nectin-4 expression in breast carcinomas. Imprint smears were obtained from 140 breast carcinoma specimens and studied immunocytochemically for the expression of Survivin and Nectin-4. The results were correlated with several clinicopathological parameters, including five-year survival. Increased Survivin staining pattern correlated with increased grade (p < 0.0001), increased lymph node invasion (p < 0.0001), increased tumor size and reduced survival (p < 0.0001). Elevated Nectin-4 expression also correlated significantly with increased grade (p < 0.0001), increased tumor size (p < 0.0001) and reduced survival (p < 0.0001). In addition, Survivin and Nectin-4 staining patterns correlated strongly with one another (p < 0.0001). However, on multivariate analysis, neither Survivin nor Nectin-4 expression seemed to have an independent impact on survival in our study cases. The findings of our study suggest that increased expression of Survivin and Nectin-4 may indicate a worse prognosis in breast cancer patients. The exact implications of the expression of these markers in breast cancer prognosis and treatment remain to be

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Intraoperative Imprint Cytologic Evaluation of Sentinel Lymph Nodes for Lobular Carcinoma of the Breast

Cited by 78 publications

References 43 publications

Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma

Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma

Is intraoperative touch imprint cytology of sentinel lymph nodes in patients with breast cancer cost effective?

The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma

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