Intraoperative irradiation of the canine pancreas: short-term effects

Heijmans, Harald J.; Mehta, D. M.; Kleibeuker, Jan H.; Sluiter, Willem; Oldhoff, J; Hoekstra, HJ

doi:10.1016/0167-8140(93)90155-2

Cited by 14 publications

(12 citation statements)

References 8 publications

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“…In another animal study, designed to study short and long term endocrine and exocrine insufficiency of the pancreatic tissue induced by IORT, authors observed a significant decrease in insulin secretion in dogs treated with 30-35 Gy IORT [21]. Contrary to endocrine function, exocrine function was not affected very much.…”

Section: Discussionmentioning

confidence: 83%

“…As a summary of these animal and human studies mentioned above [5][6][7][19][20][21][22][23][24][25][26], there is relative sensitivity of the exocrine part of the pancreas to irradiation in comparison to the endocrine part of the organ. Vascular damage is the most common cause of radiation toxicity [5][6][7][19][20][21][22][23][24][25][26].…”

Section: Discussionmentioning

confidence: 96%

“…Vascular damage is the most common cause of radiation toxicity [5][6][7][19][20][21][22][23][24][25][26]. The irradiated pancreatic tissue shrinks in size and becomes extremely fibrotic.…”

Section: Discussionmentioning

confidence: 99%

“…Acinar cells of the pancreas are much more sensitive to radiation damage than islet cells and the pathophysiology of radiation damage is mainly due to chronic vascular injury with eventual fibrosis and atrophy of the gland [5][6][7][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

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Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer

Gemici

Sargın

Uygur-Bayramiçli

et al. 2013

Radiotherapy and Oncology

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 96%

“…Vascular damage is the most common cause of radiation toxicity [5][6][7][19][20][21][22][23][24][25][26]. The irradiated pancreatic tissue shrinks in size and becomes extremely fibrotic.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer

Gemici

Sargın

Uygur-Bayramiçli

et al. 2013

Radiotherapy and Oncology

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“…In the study of Heijmanns et al 16 a significant decrease within insulin secretion in dogs treated with 30-35 Gy IORT. In contrast to endocrine function, exocrine function was affected too much.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Chemoradiotherapy at Gastric Cancer on Pancreatic Enzymes and Pancreas Volume.

Kandaz¹

2017

UHOD

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Post-operative chemoradiotherapy is one of the therapeutic approaches for operated gastric cancer. During radiotherapy planning, pancreas has not been accepted as a critical organ until now, thus toxicity to pancreas has not been considered. In our prospective study, serum pancreatic enzyme levels and pancreatic volume after RT is investigated. Seventy-one patients with gastric cancer were evaluated adjuvant chemoradiotherapy. Mean pancreas volume, mean pancreas radiotherapy dose and V5, V10, V20 and V40 values were calculated. Fasting blood glucose, insulin, amylase and glycosylated hemoglobin levels were evaluated before radiotherapy and re-evaluated at the end of radiotherapy, at 1th, 3rd, 6th and 12th months after radiotherapy. Pancreas volume was evaluated before radiotherapy and re-evaluated at 12th month after radiotherapy. Before the initiation, after the first session and at the 1th, 3th, 6th and 12th months of radiotherapy, difference between serum Fasting blood glucose (p= 0.179), insulin (p= 0.296), HbA1c (p= 0.468) and amylase levels (p= 0.069) levels were not statistically significant but there is statistically significant decrease in pancreatic volume after treatment (p= 0.002). Postoperative chemoradiotherapy is able to prolong survival and decrease recurrence in operated gastric cancer patients. In our prospective study, we could not identify any statistically significant finding related to pancreatic toxicity or its presentation on biochemical parameters except pancreas atrophy in one-year period. Although, there was not any self-reported diabetes mellitus at early period it, follow-up needed for late toxicity. Keywords: Chemoradiotherapy, Gastric cancer, Pancreatic enzymes, Pancreas volume ÖZET Mide Kanserinde Kemoradyoterapinin Pankreas Hacmi ve Pankreas Enzimleri Üzerine EtkisiPost-operatif kemoradyoterapi, ameliyat edilen mide kanseri için terapötik yaklaşımlardan biridir. Radyoterapi planlaması sırasında şimdiye kadar pankreas kritik bir organ olarak kabul edilmemiştir, bu nedenle pankreas toksisitesi dikkate alınmamıştır. Prospektif çalışmamızda, radyoterapi sonrası serum pankreatik enzim düzeyleri ve pankreas hacmi araştırılmıştır. Adjuvan kemoradyoterapi uygulanan 71 mide kanserli hasta değerlendirildi. Ortalama pankreas hacmi, ortalama pankreas radyoterapi dozu ve V5, V10, V20 ve V40 değerleri hesaplandı. Açlık kan şekeri, insülin, amilaz ve glikolize hemoglobin düzeyleri radyoterapi öncesi değerlendirildi ve radyoterapi bitiminde, radyoterapiden sonra 1, 3, 6. ve 12. aylarda yeniden değerlendirildi. Pankreas hacmi radyoterapi öncesi değerlendirildi ve radyoterapiden sonraki 12. ayda yeniden değerlendirildi. Radyoterapi öncesi, radyoterapi bitiminde, radyoterapiden sonra 1, 3, 6. ve 12. aylarda serum açlık kan glikozu (p= 0.179), insülin (p= 0.296), HbA1c (p= 0.468) ve amilaz düzeyleri istatistiksel olarak anlamlı değildi (p= 0.069), ancak tedavi sonrası pankreas hacminde istatistiksel olarak anlamlı bir azalma vardı (p= 0.002). Postoperatif kemoradyoterapi ameliyat edilen mide...

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