Intraoperative Irrigation and Risk of Chronic Subdural Hematoma Recurrence

Schack, Anders; Rønn Jensen, Thorbjørn Søren; Jensen, Mette Haldrup; Miscov, Rares; Sindby, Ann Kathrine; Fugleholm, Kåre; Bergholt, Bo; Bjarkam, Carsten Reidies; Poulsen, Frantz Rom; Grønhøj, Mads Hjortdal

doi:10.1227/ons.0000000000000941

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…Therefore, this study advocates that the minimum duration of subdural drainage should be at least 12 h, and that the exact position and duration of the drain should be left to the discretion of the attending physician. Similarly, as the optimal volume for irrigation is not yet known [ 29 ], the practical volume used in this study is also left to the discretion of the attending physician, with a minimum volume of 200 ml. This approach highlights the importance of clinical judgment in the absence of conclusive evidence and ensures flexibility in patient care while adhering to minimum standards.…”

Section: Interventionsmentioning

confidence: 99%

Efficacy of intraoperative irrigation with artificial cerebrospinal fluid in chronic subdural hematoma surgery: study protocol for a multicenter randomized controlled trial

Nagashima,

Araki,

Nishida

et al. 2024

Trials

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Background The surgical techniques for treatment of chronic subdural hematoma (CSDH), a common neurosurgical condition, have been discussed in a lot of clinical literature. However, the recurrence proportion after CSDH surgery remains high, ranging from 10 to 20%. The standard surgical procedure for CSDH involves a craniostomy to evacuate the hematoma, but irrigating the hematoma cavity during the procedure is debatable. The authors hypothesized that the choice of irrigation fluid might be a key factor affecting the outcomes of surgery. This multicenter randomized controlled trial aims to investigate whether intraoperative irrigation using artificial cerebrospinal fluid (ACF) followed by the placement of a subdural drain would yield superior results compared to the placement of a subdural drain alone for CSDH. Methods The study will be conducted across 19 neurosurgical departments in Japan. The 1186 eligible patients will be randomly allocated to two groups: irrigation using ACF or not. In either group, a subdural drain is to be placed for at least 12 h postoperatively. Similar to what was done in previous studies, we set the proportion of patients that meet the criteria for ipsilateral reoperation at 7% in the irrigation group and 12% in the non-irrigation group. The primary endpoint is the proportion of patients who meet the criteria for ipsilateral reoperation within 6 months of surgery (clinical worsening of symptoms and increased hematoma on imaging compared with the postoperative state). The secondary endpoints are the proportion of reoperations within 6 months, the proportion being stratified by preoperative hematoma architecture by computed tomography (CT) scan, neurological symptoms, patient condition, mortality at 6 months, complications associated with surgery, length of hospital stay from surgery to discharge, and time of the surgical procedure. Discussion We present the study protocol for a multicenter randomized controlled trial to investigate our hypothesis that intraoperative irrigation with ACF reduces the recurrence proportion after the removal of chronic subdural hematomas compared with no irrigation. Trial registration ClinicalTrials.gov jRCT1041220124. Registered on January 13, 2023.

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Section: Interventionsmentioning

confidence: 99%