Intraoperative Lung Ultrasound (ILU) for the Assessment of Pulmonary Nodules

Taurchini, Marco; Quarato, Carla Maria Irene; Frongillo, Elisabetta; Ferretti, Gian Maria; Cipriani, Cristiana; Bizzarri, M.; Barbaro, Maria Pia Foschino; Lacedonia, Donato; Simeone, Annalisa; Graziano, Paolo; Dimitri, L.; Maiello, Evaristo; Cavaliere, Lucio; Cosmo, Salvatore De; Sperandeo, Marco

doi:10.3390/diagnostics11091691

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…Our first results and practical experience confirm that pulmonary tumours of different sizes (0.6 cm-4.6 cm) and a maximum distance of 6.4 cm to the lung surface can be reliably found intraoperatively by B-mode. This has also been demonstrated in other studies compared to results obtained via manual palpation [3]. Previous studies primarily investigated the value of intrathoracic ultrasound in terms of its ability to detect pulmonary nodules and compared the results with intraoperative palpation [3,5,17].…”

Section: Discussionmentioning

confidence: 59%

“…This has also been demonstrated in other studies compared to results obtained via manual palpation [3]. Previous studies primarily investigated the value of intrathoracic ultrasound in terms of its ability to detect pulmonary nodules and compared the results with intraoperative palpation [3,5,17]. In particular, Khereba et al demonstrated the high utility of intraoperative ultrasound for pulmonary nodule detection in minimally invasive thoracic surgery [6].…”

Section: Discussionmentioning

confidence: 77%

“…The extent of resection in cases of SPNs of an unclear entity is decisive and continues to depend on the intraoperative frozen section result. The use of intrathoracic ultrasonography during thoracic surgery has been described as a safe method for localizing SPNs in several studies [3][4][5][6][7]. These studies have demonstrated that intrathoracic ultrasound can reliably detect SPNs and showed no disadvantage compared to manual palpation [4,8].…”

Section: Introductionmentioning

confidence: 99%

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Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) in Minimally Invasive Thoracic Surgery for Characterization of Pulmonary Tumours: A Clinical Feasibility Study

Schauer

Jung

Silva

et al. 2023

Cancers

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Background: The intraoperative detection of solitary pulmonary nodules (SPNs) continues to be a major challenge, especially in minimally invasive video-assisted thoracic surgery (VATS). The location, size, and intraoperative frozen section result of SPNs are decisive regarding the extent of lung resection. This feasibility study investigates the technical applicability of intraoperative contrast-enhanced ultrasonography (Io-CEUS) in minimally invasive thoracic surgery. Methods: In this prospective, monocentric clinical feasibility study, n = 30 patients who underwent Io-CEUS during elective minimally invasive lung resection for SPNs between October 2021 and February 2023. The primary endpoint was the technical feasibility of Io-CEUS during VATS. Secondary endpoints were defined as the detection and characterization of SPNs. Results: In all patients (female, n = 13; mean age, 63 ± 8.6 years) Io-CEUS could be performed without problems during VATS. All SPNs were detected by Io-CEUS (100%). SPNs had a mean size of 2.2 cm (0.5–4.5 cm) and a mean distance to the lung surface of 2.0 cm (0–6.4 cm). B-mode, colour-coded Doppler sonography, and contrast-enhanced ultrasound were used to characterize all tumours intraoperatively. Significant differences were found, especially in vascularization as well as in contrast agent behaviour, depending on the tumour entity. After successful lung resection, a pathologic examination confirmed the presence of lung carcinomas (n = 17), lung metastases (n = 10), and benign lung tumours (n = 3). Conclusions: The technical feasibility of Io-CEUS was confirmed in VATS before resection regarding the detection of suspicious SPNs. In particular, the use of Doppler sonography and contrast agent kinetics revealed intraoperative specific aspects depending on the tumour entity. Further studies on Io-CEUS and the application of an endoscopic probe for VATS will follow.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) in Minimally Invasive Thoracic Surgery for Characterization of Pulmonary Tumours: A Clinical Feasibility Study

Schauer

Jung

Silva

et al. 2023

Cancers

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“…Preoperative electromagnetic navigational bronchoscopy (ENB) is safe and precise for injecting indocyanine green or iodized oil [19][20][21][22] but is complex, costly, and di cult to generalize. Intraoperative ultrasound is a noninvasive and straightforward approach [23,24] but may fail if the lung tissue is poorly collapsed or contains gas. Three-dimensional reconstruction is noninvasive but requires additional time and technical expertise to create a lung model [25].…”

mentioning

confidence: 99%

Clinical application of CT-assisted body surface localization combined with intraoperative stereotactic anatomical localization in thoracoscopic lung nodule resection: A single-centre retrospective study

Zhu,

Chen,

Zhu

et al. 2024

Preprint

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Background To evaluate the clinical value of CT-assisted body surface localization combined with intraoperative stereotactic anatomical localization in thoracoscopic lung nodule resection. Methods We retrospectively collected the clinical data of 120 patients who underwent lung nodule localization and resection surgery at the Department of Thoracic Surgery, First Affiliated Hospital of Bengbu Medical College, from January 2020 to January 2022. Among them, 30 patients underwent CT-assisted body surface localization combined with intraoperative stereotactic anatomical localization, 30 patients underwent only CT-assisted body surface localization, 30 patients underwent only intraoperative stereotactic anatomical localization, and 30 patients underwent CT-guided percutaneous microcoil localization. The success rates, complication rates, and localization times of the four lung nodule localization methods were statistically analysed. Results The success rates of CT-assisted body surface localization combined with intraoperative stereotactic anatomical localization and CT-guided percutaneous microcoil localization were both 96.7%, which were significantly higher than the 70.0% success rate in the CT-assisted body surface localization group (P < 0.05). The complication rate in the combined group was 0%, which was significantly lower than the 60% in the microcoil localization group (P < 0.05). The localization time for the combined group was 17.73 ± 2.52 min, which was significantly less than that (27.27 ± 7.61 min) for the microcoil localization group (P < 0.05). Conclusions CT-assisted body surface localization combined with intraoperative stereotactic anatomical localization is a safe, painless, accurate, and reliable method for lung nodule localization.

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“…Almost 2 decades ago, Santambrogio et al [ 10 ] utilized IUS to safely and effectively locate and resect non-palpable PNs in 18 patients. Recently, Taurchini et al [ 11 ] utilized IUS to identify and locate suspicious lung nodules in 131 patients undergoing either thoracoscopic or open thoracotomy resection. The detection rate of lung nodules for ultrasound was 100% compared to digital palpation which was 94.66% [ 11 ].…”

mentioning

confidence: 99%