Intraoperative Near‐infrared Imaging for Parathyroid Gland Identification by Auto‐fluorescence: A Feasibility Study

Leeuw, Frédéric De; Breuskin, Ingrid; Abbaci, Muriel; Casiraghi, Odile; Mirghani, Haïtham; Lakhdar, Aïcha Ben; Laplace‐Builhé, Corinne; Hartl, Dana M.

doi:10.1007/s00268-016-3571-5

Cited by 143 publications

(122 citation statements)

References 27 publications

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“…So far, the only method insensitive to light is the PTeye device [55]. Furthermore, NIR shows a limited ability to localize PGs covered deeply by other tissues since the penetration of light is a few millimeters of soft fatty-fibrous tissue [58,64].…”

Section: Near-infrared Autofluorescencementioning

confidence: 99%

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

et al. 2020

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Accurate pre-operative determination of parathyroid glands localization is critical in the selection of minimally invasive parathyroidectomy as a surgical treatment approach in patients with primary hyperparathyroidism (PHPT). Its importance cannot be overemphasized as it helps to minimize the harmful side effects associated with damage to the parathyroid glands such as in hypocalcemia, severe hemorrhage or recurrent laryngeal nerve dysfunction. Preoperative and intraoperative methods decrease the incidence of mistakenly injuring the parathyroid glands and allow for the timely diagnosis of various abnormalities, including parathyroid adenomas. This article reviews 139 studies conducted between 1970 and 2020 (49 years). Studies that were reviewed focused on several techniques including application of carbon nanoparticles, carbon nanoparticles with technetium sestamibi (99m Tc-MIBI), Raman spectroscopy, near-infrared autofluorescence, dynamic optical contrast imaging, laser speckle contrast imaging, shear wave elastography, and indocyanine green to test their potential in providing proper parathyroid glands’ localization. Apart from reviewing the aforementioned techniques, this study focused on the applications that helped in the detection of parathyroid adenomas. Results suggest that applying all the reviewed techniques significantly improves the possibility of providing proper localization of parathyroid glands, and the application of indocyanine green has proven to be the ‘ideal’ approach for the diagnosis of parathyroid adenomas.

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Section: Near-infrared Autofluorescencementioning

confidence: 99%

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

et al. 2020

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“…Also in 2016, de Leeuw et al studied parathyroid autofluorescence using Fluobeam 800 ® (Fluoptics, Grenoble, France) both intraoperatively and ex vivo. NIR imaging was performed on surgical specimens from 28 patients to detect any iatrogenically resected parathyroid glands.…”

Section: Introductionmentioning

confidence: 99%

The use of near‐infrared fluorescence imaging in endocrine surgical procedures

Kahramangil

Berber

2017

Journal of Surgical Oncology

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Near-infrared fluorescence imaging in endocrine surgery is a new, yet highly investigated area. It involves indocyanine green use as well as parathyroid autofluorescence. Several groups have described their technique and reported on the observed utility. However, there is no consensus on technical details. Furthermore, the correlation between intraoperative findings and postoperative outcomes is unclear. With this study, we aim to review the current literature on fluorescence imaging and share our insights on technical details.

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“…It has been reported to consistently identify PGs across various disease states, and unlike ICGF, does not require administration of a fluorescent dye (10). Of note, parathyroid AF persists regardless of gland viability and can be detected even after surgical resection of the gland (11).…”

mentioning

confidence: 96%

Comparison of indocyanine green fluorescence and parathyroid autofluorescence imaging in the identification of parathyroid glands during thyroidectomy

Kahramangil

Berber

2017

Gland Surg.

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Intraoperative Near‐infrared Imaging for Parathyroid Gland Identification by Auto‐fluorescence: A Feasibility Study

Abstract: Real-time NIR imaging based on parathyroid auto-fluorescence is fast, safe, and non-invasive and shows very encouraging results, for intraoperative parathyroid identification.

Cited by 143 publications

References 27 publications

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

The use of near‐infrared fluorescence imaging in endocrine surgical procedures

Comparison of indocyanine green fluorescence and parathyroid autofluorescence imaging in the identification of parathyroid glands during thyroidectomy

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