Intraoperative power Doppler ultrasonography with a contrast-enhancing agent for intracranial tumors

Kanno, Hiroshi; Ozawa, Yukihiko; Sakata, Katsumi; Sato, Hidemitsu; Tanabe, Yutaka; Shimizu, Nobuyuki; Yamamoto, Isao

doi:10.3171/jns.2005.102.2.0295

Cited by 58 publications

(41 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Compared with regular ultrasound imaging, CEUS can provide tumor perfusion information and can potentially be complementary by each other with the use of MRI, CT, MR angiography, or CT angiography as imaging method for evaluating brain lesions and vessels both in transcranial ultrasound 41 and intracranial ultrasound during intraoperative procedure. 16,17 The contrast agent used in CEUS, or the microbubble contrast agent, is a pure blood pool agent. It remains in the vasculature and leads to the change of TIC.…”

Section: Discussionmentioning

confidence: 99%

“…Several techniques have been developed to overcome this issue such as transcranial ultrasound 15 and intraoperative ultrasound. 16,17 In transcranial ultrasound, the ultrasound wave passes through the temporal, occipital, and eye window. When a patient goes through brain surgery or stereotactic brachytherapy, craniotomy or craniectomy makes ultrasound imaging accessible.…”

Section: Introductionmentioning

confidence: 99%

“…When a patient goes through brain surgery or stereotactic brachytherapy, craniotomy or craniectomy makes ultrasound imaging accessible. 3,15,16 Clinical ultrasound is a real-time, low-cost, nonionizing, and portable imaging method that has been widely used in diagnosis and in interventional therapies. With the development of new contrast agents to visualize blood flow in the microcirculation and larger vasculatures, commonly referred to as microbubbles, contrast-enhanced ultrasound (CEUS) is becoming popular in a number of areas where perfusion is an important clinical differentiator.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quantitative correlational study of microbubble‐enhanced ultrasound imaging and magnetic resonance imaging of glioma and early response to radiotherapy in a rat model

et al. 2015

View full text Add to dashboard Cite

Purpose: Radiotherapy remains a major treatment method for malignant tumors. Magnetic resonance imaging (MRI) is the standard modality for assessing glioma treatment response in the clinic. Compared to MRI, ultrasound imaging is low-cost and portable and can be used during intraoperative procedures. The purpose of this study was to quantitatively compare contrast-enhanced ultrasound (CEUS) imaging and MRI of irradiated gliomas in rats and to determine which quantitative ultrasound imaging parameters can be used for the assessment of early response to radiation in glioma. Methods: Thirteen nude rats with U87 glioma were used. A small thinned skull window preparation was performed to facilitate ultrasound imaging and mimic intraoperative procedures. Both CEUS and MRI with structural, functional, and molecular imaging parameters were performed at preradiation and at 1 day and 4 days postradiation. Statistical analysis was performed to determine the correlations between MRI and CEUS parameters and the changes between pre-and postradiation imaging. Results: Area under the curve (AUC) in CEUS showed significant difference between preradiation and 4 days postradiation, along with four MRI parameters, T 2 , apparent diffusion coefficient, cerebral blood flow, and amide proton transfer-weighted (APTw) (all p < 0.05). The APTw signal was correlated with three CEUS parameters, rise time (r = −0.527, p < 0.05), time to peak (r = −0.501, p < 0.05), and perfusion index (r = 458, p < 0.05). Cerebral blood flow was correlated with rise time (r = −0.589, p < 0.01) and time to peak (r = −0.543, p < 0.05). Conclusions: MRI can be used for the assessment of radiotherapy treatment response and CEUS with AUC as a new technique and can also be one of the assessment methods for early response to radiation in glioma. C 2015 American Association of Physicists in Medicine.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative correlational study of microbubble‐enhanced ultrasound imaging and magnetic resonance imaging of glioma and early response to radiotherapy in a rat model

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Nonetheless its use in cerebral surgery has only been attempted few times so far [25][26][27], and there are no guidelines provided on this regard.…”

Section: Introductionmentioning

confidence: 99%

201 Intraoperative Cerebral Glioma Characterization With Contrast Enhanced Ultrasound

Prada¹,

Mattei²,

Filippini³

et al. 2014

Neurosurgery

View full text Add to dashboard Cite

Background. Contrast enhanced ultrasound (CEUS) is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. Nevertheless its intraoperative use for brain tumors visualization has been performed few times, and a thorough characterization of cerebral glioma had never been performed before. Aim. To perform the first characterization of cerebral glioma using CEUS and to possibly achieve an intraoperative differentiation of different gliomas. Methods. We performed CEUS in an off-label setting in 69 patients undergoing surgery for cerebral glioma. An intraoperative qualitative analysis was performed comparing iCEUS with B-mode imaging. A postprocedural semiquantitative analysis was then performed for each case, according to EFSUMB criteria. Results were related to histopathology. Results. We observed different CE patterns: LGG show a mild, dotted CE with diffuse appearance and slower, delayed arterial and venous phase. HGG have a high CE with a more nodular, nonhomogeneous appearance and fast perfusion patterns. Conclusion. Our study characterizes for the first time human brain glioma with CEUS, providing further insight regarding these tumors' biology. CEUS is a fast, safe, dynamic, real-time, and economic tool that might be helpful during surgery in differentiating malignant and benign gliomas and refining surgical strategy.

show abstract

“…For example, to assess tissue perfusion during interventional treatment of solid tumors, evaluate necrotic tissue in pancreatitis, and define the scope of the injured area in solid organs such as the liver, spleen, and kidney (Golea et al, 2010;Moschouris et al, 2010;Lv et al, 2011). Most recently, intraoperative CEUS has guided the surgical scope of intracranial occupying masses and evaluated the effect of surgery (Kanno et al, 2005;He et al, 2008). The contrast agents for CEUS -microbubbles -are pure blood pool contrast agents that do not enter the interstitial space; thus, can be used to visualize changes in microcirculation and perfusion of the tissue, thus objectively evaluating tissue activity and functionality (Cosgrove, 2006).…”

Section: Introductionmentioning

confidence: 99%

Conventional and contrast-enhanced ultrasound assessment of craniocerebral gunshot wounds

Deng¹,

Dan²,

Tao³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. This study aimed to investigate the characteristic features of craniocerebral gunshot wounds by conventional ultrasound (CUS) and evaluate the efficacy of contrast-enhanced ultrasound (CEUS) in differentiation of tissue condition in wounds. Twenty crossbreed dogs (treatment: N = 15; control: N = 5) were used in the study. Pipe-shaped hyperechoes of varying size were found by CUS in most of the treated animals. The echoic areas were distinct from the neighboring brain tissue and did not change with time. CEUS revealed that the pipeshaped echo was unenhanced in majority of the injured brains and the surrounding tissue was either heterogeneously enhanced or unenhanced. Pathological analysis confirmed that the contrast-filling-defect area indicated necrotic tissue and the heterogeneous minimally enhanced areas indicated degenerative tissue. CUS imaging enabled detection of hematomas and CEUS indicated that the filling defect was in the center of the hematoma, with enhancement gradually increasing towards the periphery. CUS could effectively detect a wound tract, hematoma, and the craniocerebral area injured by a gunshot, while CEUS could accurately reveal necrotic tissue in the injured area and differentiate the degenerative from normal tissue.

show abstract

Intraoperative power Doppler ultrasonography with a contrast-enhancing agent for intracranial tumors

Abstract: Intraoperative power Doppler ultrasonography performed using a contrast-enhancing agent can facilitate intraoperative real-time navigation and assessment of the intratumoral vasculature and peritumoral vessels, particularly for tumors having abundant vessels such as hemangioblastomas.

Cited by 58 publications

References 15 publications

Quantitative correlational study of microbubble‐enhanced ultrasound imaging and magnetic resonance imaging of glioma and early response to radiotherapy in a rat model

Quantitative correlational study of microbubble‐enhanced ultrasound imaging and magnetic resonance imaging of glioma and early response to radiotherapy in a rat model

201 Intraoperative Cerebral Glioma Characterization With Contrast Enhanced Ultrasound

Conventional and contrast-enhanced ultrasound assessment of craniocerebral gunshot wounds

Contact Info

Product

Resources

About