Intraoperative radiolymphoscintigraphy for detection of occult nodal metastasis in patients with head and neck squamous cell carcinoma

Zitsch, Robert P.; Todd, Daniel W.; Renner, Gregory J.; Singh, Amolak

doi:10.1067/mhn.2000.104017

Cited by 21 publications

(2 citation statements)

References 18 publications

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“…Early data from the University of Miami series as well as a series from the University of Missouri [41] was presented to the American College of Surgeons Oncology Group in 2001, and ultimately led to the development of a multi-institutional validation trial of sentinel node biopsy for early invasive oral cancer, which recently completed accrual (see ACOSOG web site: www.acosog.org). This trial involved 25 institutions and 34 certified surgeons and involved a formal training program.…”

Section: The Acosog Z0360 Validation Trialmentioning

confidence: 99%

Sentinel node biopsy in oral squamous cell carcinoma

Civantos

Zitsch

Bared

2007

Journal of Surgical Oncology

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The clinical utility of sentinel node biopsy techniques for cutaneous melanoma has led multiple investigators to study the applicability of this approach to other solid tumors, including cancers of the upper aerodigestive tract, and especially the oral cavity. Preliminary data indicate that it may be useful for early oral cancers, with the exception of floor of mouth tumors, where technical challenges related to the proximity of the lymphatic basin remain a problem. A multi-institutional pathologic validation trial, involving sentinel node biopsy followed by completion selective neck dissection, has completed accrual. While central step sectioning and immunohistochemistry remain to be completed and analyzed, routine pathologic techniques provided negative predictive values of 96% for oral cancer excluding floor of mouth lesions. Subsequent trials need to involve clinical follow-up and evaluation for recurrence in the neck. We believe this technique may ultimately play a role in the management of early oral cancer.

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Section: The Acosog Z0360 Validation Trialmentioning

confidence: 99%

Sentinel node biopsy in oral squamous cell carcinoma

Civantos

Zitsch

Bared

2007

Journal of Surgical Oncology

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“…Un trenn bar ver bun den ist die Me tho de mit der Fra ge der The ra pie des kli nisch me ta sta sen frei en Hal ses (cN0), da hier die bild ge ben den Dia gno se ver fah ren eine Ge nau ig keit von nicht mehr als 80 lie fern [27]. Da her wird für die end gül tige Sta di en zu tei lung (das Sta ging) des Halses in der Re gel we nigs tens eine elek ti ve su prao mo hyoi da le Neck-Diss ec ti on (ND) durch ge führt [22].Um die Me tho de der SNB zu va li dieren, ist sie des halb in prak tisch al len veröf fent lich ten Stu di en pa ral lel zu ei ner ND durch ge führt wor den [2,4,5,6,7,8,9,10,13,14,16,21, 23,25,26,29,32,34,35,38]. Die Er geb nis se die ser Stu di en, ins be son dere die fast 100ige Iden ti fi ka ti ons ra te der Sen ti nel-Lymph kno ten (SLK) und die gerin ge Rate an falsch-ne ga ti ven Be fun den, er öff ne te früh zei tig die Chan ce, auf eine par al le le elek ti ve ND zu ver zich ten.…”

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