Intraoperative Radiotherapy in the Multidisciplinary Treatment of Pediatric Tumors a Preliminary Report on Initial Results

Sierrasesúmaga, Luis; Martín, Isabel Rodríguez; Santos, Mauro Augusto dos; Voltas, J; Berián, J.M.; Canadell, J.

doi:10.3109/02841868909111259

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…In the field of pediatric oncology, IORT appears as an, interesting alternative to the use of extensive external radiation areas [35]. In selected patients it seems feasible to combine IORT (10-15 Gy) with external radiation at doses lower than have classically been considered optimal (15% to 25% reduction), thus reducing toxicity in healthy tissues.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative radiotherapy in the multidisciplinary treatment of bone sarcomas in children and adolescents

Urbina

Sierrasesúmaga

Abuchaibe

et al. 1991

Med. Pediatr. Oncol.

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From September 1984 to December 1989, 38 patients of pediatric age with localized bone sarcomas received intraoperative radiotherapy (IORT) as part of a multidisci plinary treatment program. The age ranged from 6 to 21 years. The tumor histologies were 22 osteosarcomas and 16 Ewing's sarcomas.Thirty‐four had initial primary disease (90%) and 4 were treated for local recurrence (10%). IORT was used on 32 untreated patients and in 6 previously treated with external beam radiotherapy (EBR). The IORT field included the surgically exposed tumor bed area. Single radiation doses ranging from 10 to 20 Gy were delivered, using 6–20 MeV electron beams. The median follow‐up time for the entire group is 25 months (2–65+ months). The projected 5‐year disease‐free and overall survival rates are 65% and 69%, respectively. One patient developed a local recurrence in each histological group: one chondroblastic osteosarcoma and one cervical Ewing's sarcoma. Six patients died from metastatic progression: 3 initially recurrent tumors and three primary disease cases. Severe neuropathy and soft tissue necrosis were seen in some patients as IORT related complications.IORT is a feasible technique to be integrated in multidisciplinary programs that may promote local control in pediatric and adolescent patients with bone sarcomas. Peripheral nerves are dose‐limiting tissue structures for IORT.

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Section: Discussionmentioning

confidence: 99%

Intraoperative radiotherapy in the multidisciplinary treatment of bone sarcomas in children and adolescents

Urbina

Sierrasesúmaga

Abuchaibe

et al. 1991

Med. Pediatr. Oncol.

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“…This child also had multiple other problems, including Grade 3 fibrosis, atrophy, and mobility and extremity function. Calvo et al previously reported soft tissue necrosis and fibrosis in 5 of 11 children's extremities treated for Ewing's sarcoma and in 2 of 8 with osteosarcoma using IORT doses of 10 -20 Gy (16).…”

Section: Vincristine Doxorubicin and Cyclophosphamidementioning

confidence: 98%

Late effects of radiotherapy for pediatric extremity sarcomas

Paulino

2004

International Journal of Radiation Oncology*Biology*Physics

171

106

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“…In intraoperative radiation therapy (IORT) a high single radiation dose is delivered to the tumor site with protection of normal uninvolved organs and tissues [1][2][3][4][5][6]. Neuroblastoma is the most common solid tumor in childhood [7].…”

Section: Introductionmentioning

confidence: 99%

Intraoperative radiation therapy for advanced neuroblastoma: the problem of securing the IORT field

et al. 2007

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The purpose of this study is to evaluate the efficacy of intraoperative radiation therapy (IORT) and the problem of securing the IORT field in advanced pediatric neuroblastoma. Between 1996 and 2005, 12 children received IORT for advanced pediatric neuroblastoma patients. Electron beam energies ranged from 10 to 12 MeV and median dose was 10 Gy (8-12 Gy). All of them had surgery with IORT against the primary tumor site and the abdominal aorta surroundings. A gross total resection (GTR) was achieved in 10 patients and subtotal resection (STR) was two patients. All of 12 patients were classified as high risk. Nine patients were alive 17-120 (mean 48 months) after diagnosis. Local tumor control was achieved in 100% of patients, of whom one experienced local recurrence outside the IORT field. At the operation, it was difficult to secure the IORT field because of the angle of the radiation cylinder in three patients. One of the three of these patients experienced local recurrence outside of the IORT field in the upper side of superior mesenteric artery and two of three patients had an external beam radiation after surgery, and there was no local recurrence. One patient had a postoperative ileus, and one patient had transient diarrhea and hydronephrosis. For advanced neuroblastoma patients, IORT produced excellent local control after surgery. However, there is a problem of securing the IORT field. For local control, it is necessary to add an external beam radiation after IORT when it is difficult to secure the IORT field.

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Intraoperative Radiotherapy in the Multidisciplinary Treatment of Pediatric Tumors a Preliminary Report on Initial Results

Cited by 13 publications

References 24 publications

Intraoperative radiotherapy in the multidisciplinary treatment of bone sarcomas in children and adolescents

Intraoperative radiotherapy in the multidisciplinary treatment of bone sarcomas in children and adolescents

Late effects of radiotherapy for pediatric extremity sarcomas

Intraoperative radiation therapy for advanced neuroblastoma: the problem of securing the IORT field

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