“…These include reduced operative times, reduced postoperative inflammation, faster visual recovery, increased patient comfort, reduced rate of intraoperative retinal break formation, avoidance of conjunctival dissection and limbal stem cell damage, and less induced corneal astigmatism. [5][6][7][8][9][10][11][12] Upon its advent, 25-G PPV was applied towards treating macular holes, idiopathic epiretinal membranes, refractory macular edema, and non-clearing vitreous hemorrhage. 13 There were concerns that fragility or inadequate variety of instrumentation may limit its usefulness in more complicated surgical disease.…”