Intraoperative scrape cytology: Adult granulosa cell tumor of ovary

Deb, Prabal; Malik, Ajay; Sinha, Kavita

doi:10.4103/0970-9371.86350

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…It is an economical, simple and quick method of intra-operative diagnosis, and does not alter the utility of the specimen for subsequent histopathology examination. [ 1 ]…”

Section: Discussionmentioning

confidence: 99%

“…This technique has been used for various organs including ovary and has been described as an effective, economical, simple, fast and reliable method with results comparable with frozen section diagnosis. [ 1 ]…”

Section: Discussionmentioning

confidence: 99%

“…The history of scrape cytology dates back to 1927 and its utility during intra-operative consultation has often been neglected in comparison to frozen sections and imprint cytology. [ 1 ] Scrape cytology could be preferred over touch preparation/imprint cytology as this technique yields more material. Its role as a potential tool in intraoperative consultation is more pertinent in institutions unequipped with frozen section facility.…”

Section: Introductionmentioning

confidence: 99%

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The role of intraoperative scrape cytology in vertebroplasty

et al. 2016

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Aims:To assess the adequacy of intraoperative scrape cytology during percutaneous vertebroplasty by correlating results with corresponding histopathology.Settings and Design:Vertebroplasty is a procedure increasingly used to treat painful vertebral compression fractures. The history and presentation of osteoporotic fractures are straightforward, but difficulty arises in differentiating infective from neoplastic lesions, especially in cases where the magnetic resonance imaging is equivocal. The procedure involves injection of polymethyl methacrylate (bone cement) into the pathological vertebral body and gives dramatic pain relief. It is indicated in osteoporotic and neoplastic lesions but contraindicated in infections. Hence, intraoperative evaluation of a specimen is essential to aid in the decision of performing vertebroplasty.Subjects and Methods:A total of 128 patients with vertebral lesions underwent core biopsy and scrape cytology from June 2006 to June 2015. Based on the findings of cytological examination, malignant lesions were subjected to vertebroplasty. In lesions with infective etiology, vertebroplasty was abandoned and antibiotic or antituberculous therapy started.Results:The overall diagnostic accuracy of scrape cytology was excellent with 97.58% cases correlating with the final histopathological diagnosis. Specificity was 100%, positive predictive value was 100% and negative predictive value was 33.33%.Conclusion:Scrape cytology is a simple, rapid, accurate cytodiagnostic technique and should be routinely utilized in vertebral lesions for intraoperative consultation and decision making during vertebroplasty.

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“…It is an economical, simple and quick method of intra-operative diagnosis, and does not alter the utility of the specimen for subsequent histopathology examination. [ 1 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of intraoperative scrape cytology in vertebroplasty

et al. 2016

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“…In some cases, it can help surgeons avoid under-treatment or overtreatment of patients. FS is indicated to ensure that the tissue sampled adequate for diagnosis, to determine the nature of the disease process, to plan ancillary studies, to determine tumor spread, and to assess margins [6] [7] The aim of the work is to evaluate the accuracy of intraoperative frozen section in the diagnosis of ovarian neoplasms in Zagazig University.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of Intraoperative Frozen Section in the Diagnosis of Ovarian Neoplasms

Abdelghany¹,

Arafa²,

Madkour³

et al. 2015

OJOG

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Objective: The aim of the work is to evaluate the accuracy of intraoperative frozen section in the diagnosis of ovarian neoplasms in Zagazig University. Design: A prospective cross sectional cohort study. Method: This study was performed between March 2011 and March 2012, on 50 patients presented with ovarian mass. Gross examination of the tumor removed was done by inspection and palpation. The specimen was then cut with a sharp knife into two halves. The most appropriate area thought to be representative of lesion was chosen. The number of sections frozen was depended on the type and size of the tumor. Seven to eight μm sections were obtained and stained with hematoxylin-eosin. The specimens were then fixed in formalin. Paraffin blocks of the sections were processed in the routine way and sections were stained with hematoxylin and eosin (H and E). The diagnosis obtained by intraoperative frozen section based on cellularity and cell morphology was compared with final histopathological diagnosis in terms of diagnostic sensitivity, to differentiate between benign and malignant lesions. Assessment of the overall accuracy of the intraoperative diagnosis was classified as concordant or discordant. Results: There was no statisticaly significant differencre in the studied patients as regard the clinical data, macroscopic and intraoperative picture, while there was statisticaly significat association as regard the laterality of the ovarian masses. The validity of frozen section in the diagnosis of benign tumour was 100% with 100% accuracy, specificity, positive predictive value, negative predictive value, while sensitivity & negative prediction for borderline tumour and specificity & positive prediction of malignant tumour were 100%, specifecity for borderline tumours was 95% while the positive predictive value was 33.3% with 96% accuracy for both malignant and borderline tumours. Conclusion: Intraoperative frozen section is accurate for rapid diagnosis of ovarian tumors. It can help surgeons avoid under-treatment or overtreatment of patients. Our study was designed prospectively

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“…It is an economical, simple and quick method of intra-operative diagnosis with acceptable sensitivity and high specificity, and does not alter the utility of the specimen for subsequent histopathology examination [6]. It can be used as an adjunct to frozen section and its routine utilization in ovarian lesions could aid in expanding the knowledge of cytology of ovarian neoplasms [7].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study between Intraoperative Frozen Section and Scrape Smear Cytology in the Diagnosis of Ovarian Neoplasm

Abdelghany¹,

Arafa²,

Madkour³

et al. 2015

OJOG

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Objective: The aim of this work is to compare between intraoperative frozen section and scrape smear cytology in the diagnosis of ovarian neoplasm. Method: This study was performed between March 2011 and March 2012, on 50 patients presented with ovarian mass. Gross examination of the tumor removed was done by inspection and palpation. The specimen was then cut with a sharp knife into two halves. The area was scraped with a sharp scalpel or the end of a glass slide, depending upon the type of tissue. A semifluid drop thus obtained was spread over a glass slide. One to four slides per case were taken from different representative areas. The slides were labelled and immediately put into 95% ethyl alcohol and stained with hematoxylin-eosin. The specimens were then fixed in formalin. Paraffin blocks of the sections were processed in the routine way and sections were stained with hematoxylin and eosin (H and E). Assessment of the overall accuracy of the intraoperative diagnosis was classified as concordant or discordant. Results: The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of scraping technique in the diagnosis of benign ovarian masses were 100%, 95.2%, 96.7%, 100% and 98% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of scraping technique in the diagnosis of border line ovarian masses were 100%, 93.4%, 25%, 100% and 94% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of scraping technique in the diagnosis of malignant ovarian masses were 80%, 100%, 100%, 88.2% and 92% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of frozen section in the diagnosis of benign ovarian masses were 100%, 100%, 100%, 100% and 100% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of frozen section in the diagnosis of borderline * Corresponding author. A. M. Abdelghany et al. 29ovarian masses were 100%, 95.9%, 33.3%, 100% and 96% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of frozen section in the diagnosis of malignant ovarian masses were 90%, 100%, 100%, 93.8% and 96% respectively. Conclusion: Frozen section is more accurate than smear preparations in the intraoperative assessment of ovarian tumors in this study. However, the cytology preparations were helpful in supporting the histological diagnoses, and in some cases, provided additional useful information. Thus, cytology has a complementary role to frozen section in the intraoperative assessment of ovarian lesions. At the centers where the facilities of frozen section are not available, intraoperative scrape cytology is a useful tool for intraoperative diagnosis of tumor.

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Intraoperative scrape cytology: Adult granulosa cell tumor of ovary

Cited by 6 publications

References 10 publications

The role of intraoperative scrape cytology in vertebroplasty

The role of intraoperative scrape cytology in vertebroplasty

Accuracy of Intraoperative Frozen Section in the Diagnosis of Ovarian Neoplasms

Comparative Study between Intraoperative Frozen Section and Scrape Smear Cytology in the Diagnosis of Ovarian Neoplasm

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