Intraoperative sentinel node identification in early stage cervical cancer using a combination of radiolabeled albumin injection and isosulfan blue dye injection

Intraoperative sentinel lymph node detection by vital dye through laparoscopy or laparotomy in early endometrial cancer

“…In the effort to avoid complete systematic lymph node dissection whenever possible, the sentinel lymph node (SLN) biopsy after intraoperative lymphatic mapping has been introduced for patients with malignancies of various organs [6][7][8][9][10]. The term ''sentinel node'' was coined in 1960 by Gould et al [11] for cancer of the parotid gland.…”

“…Therefore, if the SLN does not contain metastases, then the remainder of the lymphatic basin also should be negative for metastases [7]. Both vital dye and radioactive colloids have been used to detect SLNs [6][7][8][9][10].…”

“…In the case of gynecological malignancies, the feasibility and reliability of SLNs detection has been investigated in vulvar and cervical cancer [8][9][10]. Several studies have also examined the feasibility of SLNs biopsy after intraoperative lymphatic mapping with both vital dyes and radioactive colloids in women with endometrial cancer but none of these studies compared the SLNs detection rates obtainable through laparoscopy or laparotomy when using vital dye as detection tracer [12][13][14][15][16][17][18][19][20].…”

Frequency and prognostic significance of HPV DNA in sentinel lymph nodes of patients with cervical cancer

“…The sentinel lymph node (SN) procedure has emerged as a less aggressive alternative [7,9,10]. Moreover, serial sectioning and immunohistochemical analysis of SN can detect micrometastasis [7,9,10].…”

Sentinel node detection with 99mTc phytate alone is satisfactory for cervical cancer patients undergoing radical hysterectomy and pelvic lymphadenectomy

“…SLNs are often detected by both preoperative radioisotope injection using 99m Tc and intraoperative blue dye injection [8][9][10][11][12][13][14][15][16][17]. However, the SLN detection rate is low with blue dye alone, and intraoperative injection into the uterine cervix is bothersome.…”