Intraoperative surgical margin clearance – Correlation of touch imprint cytology, frozen section diagnosis, and histopathological diagnosis

Tamhane, Ankita; Shukla, Samarth; Acharya, Sourya; Acharya, Neema; Hiwale, Kishor; Bhake, Arvind

doi:10.4103/ijabmr.ijabmr_325_18

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…e reason for inability to arrive at diagnosis in both these studies was hypocellularity as also in the present study. In another study by Tamhane et al [11], tissue imprint cytology (TIC) did not give satisfactory cell yield, and falsenegative rates of TIC were significant as cell sampling was not satisfactory. In the study by Dutta et al [14], inadequate imprint smears were obtained in 12.2% of soft tissue tumor cases.…”

Section: Discussionmentioning

confidence: 99%

“…Frozen section or imprint cytology can be utilized for intraoperative evaluation of soft tissue tumors [10]. Touch imprint cytology (TIC) and frozen section diagnosis are valuable intraoperative guides for the management of malignancies as they help make a prompt therapeutic decision that may prevent surgical reintervention [11]. Imprint cytology is a technique in which imprints are obtained from the freshly cut surface of fresh unfixed tissue for evaluation [12].…”

Section: Introductionmentioning

confidence: 99%

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Role of Intraoperative Pathology Consultation by Imprint and Scrape Cytology in Soft Tissue Tumors and Tumor-Like Lesions

Gautam

Mohan

Handa

et al. 2021

Sarcoma

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Intraoperative pathologic consultation plays an essential role in therapeutic decision making, possibly avoiding under or overtreatment of the patient. Common indications for intraoperative consultation include obtaining a diagnosis in an unknown pathology, ruling out malignancy, confirming a provisional diagnosis, and assessing margin status. Fifty patients undergoing surgery for soft tissue tumors or tumor-like lesions were included in the present prospective study to evaluate the role of intraoperative pathologic consultation by imprint and scrape cytology. Careful and quick gross examination of the specimen was performed, followed by processing for imprint and scrape smears. The prepared smears were evaluated by three pathologists and the cytological diagnosis compared subsequently with final histopathological diagnosis. Intraoperative consultation was primarily requested to make or confirm preoperative diagnosis. In 44.0% cases, no previous tissue/cytological diagnosis was available. In 56.0% cases, previous pathological diagnosis was available, but the reports were inconclusive or were reported from outside our institute. The diagnostic yield of imprint smears was 24% (5 malignant, 6 benign, and 1 inconclusive), and scrape smears was 100% (10 malignant, 38 benign, and 2 inconclusive). Paraffin-embedded sections yielded diagnosis in 100% cases (11 malignant, 38 benign, and 1 nonneoplastic). Imprint smears alone were not of much help in intraoperative diagnosis. Scrape smears were found to be superior to imprint smears in terms of diagnostic yield and accuracy. Combined imprint and scrape smear cytology did not provide any advantage in intraoperative provisional tissue diagnosis in soft tissue tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of Intraoperative Pathology Consultation by Imprint and Scrape Cytology in Soft Tissue Tumors and Tumor-Like Lesions

Gautam

Mohan

Handa

et al. 2021

Sarcoma

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Diagnostic accuracy of intraoperative frozen section for margin evaluation of oral cavity squamous cell carcinoma

Ali,

Mallick,

Rashid

et al. 2024

BMC Res Notes

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Objectives Intraoperative frozen-section evaluation is a valuable technique for detecting positive margins intraoperatively for oral squamous cell carcinoma. We conducted this study to determine the diagnostic accuracy of frozen section in detecting margin status and the effect of tumor grade and stage on diagnostic accuracy. Results A total of 251 biopsy-proven cases of oral squamous cell carcinoma were included in this study. The tissue specimen resected during surgery was sent to the laboratory for frozen section evaluation. The frozen section results were then compared with the permanent section results to determine the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy. The mean age of the patients included in the study was 51.65 ± 10.03 years, with male predominance (55.4%). The overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of frozen section were 88.81%, 94.84%, 95.20%, 88.10%, and 91.63%, respectively. We conclude that frozen section is a useful technique in determining the margin status intraoperatively in oral cancers, with high diagnostic accuracy. Moreover, certain clinical parameters such as age, gender, disease duration, and tumor stage and grade appear to affect the diagnostic accuracy of frozen section.

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Intraoperative surgical margin clearance – Correlation of touch imprint cytology, frozen section diagnosis, and histopathological diagnosis

Cited by 2 publications

References 15 publications

Role of Intraoperative Pathology Consultation by Imprint and Scrape Cytology in Soft Tissue Tumors and Tumor-Like Lesions

Role of Intraoperative Pathology Consultation by Imprint and Scrape Cytology in Soft Tissue Tumors and Tumor-Like Lesions

Diagnostic accuracy of intraoperative frozen section for margin evaluation of oral cavity squamous cell carcinoma

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