Intraoperative Thrombosis of Right Coronary Artery Drug-Eluting Stent After 2 Years of Dual Antiplatelet Therapy

Abstract

This study presents the case of intraoperative thrombosis of a right coronary drug-eluting stent and subsequent right heart ischemia more than 2 years poststent placement and after recent withdrawal of clopidogrel therapy. Dual antiplatelet therapy had been continued uninterrupted since placement until 7 days prior to surgery when clopidogrel was stopped. This case highlights the emerging evidence that drug-eluting stents are susceptible to late occlusive thrombosis on acute withdrawal of antiplatelet therapy. Right heart ischemia resolved with rapid intraoperative management and emergent cardiac catheterization. This emphasizes the necessity of immediate availability to cardiac interventional facilities, which can influence outcomes.

Neurosurgery in a patient on dual antiplatelet therapy. Case report and the review of the literature

“…В отношении этого вопроса существуют различные рекомендации, но общепринятым в случае лекарственных стентов является проведение ДАТ в течение года с момента установки стента, с последующим переходом на монотерапию АСС [51]. Анализ данных литературы, однако, не подтверждает безопасность такого подхода [52,53].…”