Intraoperative ultrasound-guided breast biopsy

Radioguided occult lesion localization (ROLL) versus wire‐guided lumpectomy for non‐palpable breast lesions: A randomized prospective evaluation

“…Other techniques developed as the ultrasonographic biopsy or Mammotomme 1 [12][13][14] have also some limitations. In order to eliminate these inconveniences and improve early detection of breast lesions, some investigators have proposed new techniques in order to perform more accurate localization of nonpalpable breast lesions [15][16][17]. One of them is the use of intraoperative ultrasound-guided breast biopsy directed mainly to malignant lesions.…”

Nonpalpable breast lesions: preoperative radiological guidance in radioguided occult lesion localisation (ROLL)

“…Relativamente poca attenzione è stata rivolta al ruolo della guida radiologica con mammografi a (Mx) e ecografi a Introduction A variety of preoperative localisation techniques for nonpalpable breast lesions has been described in the literature: hypodermic needles, wires (the most widely accepted technique), carbon solution, methylene blue dye [1][2][3][4][5][6][7][8][9][10]. Ultrasound-guided intraoperative lesion localisation and placement of a radioactive seed have also been proposed [11][12][13][14]. Radioguided occult lesion localisation (ROLL), introduced in 1998, involves the inoculation of macroaggregates of human serum albumin labelled with radioactive technetium 99 (99mTc) directly into the site of a nonpalpable breast lesion, with mammography (Mx) or ultrasound (US) guidance.…”

“…Sono state inoltre proposte la localizzazione della lesione con guida ecografi ca intraoperatoria ed il posizionamento di semino radioattivo [11][12][13][14]. La radioguided occult lesion localization (ROLL), introdotta nel 1998, prevede l'inoculo di macro-aggregati di albumina umana marcata con tecnezio 99 radioattivo (99mTc) direttamente nella sede della lesione mammaria non palpabile, con guida mammografi ca o ecografi ca.…”

Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

“…Such tools would enable the surgeon to more effectively remove all tumor during the initial surgery, hence reducing re-excision rates. A range of intraoperative techniques are currently used, including: frozen section analysis [8], imprint cytology [9], intraoperative specimen radiography [10] and intraoperative ultrasound [11]. However, these techniques are time consuming and reported positive margin rates using these techniques are greater than 20% [12].…”