“…Indications of potential VAE include hypotension, sudden drop in ETCO 2 with no change in ventilation settings or drop in oxygen saturations depending on FiO 2 . The neurosurgeon is alerted while the Sudden decrease in EtCO2 by≥2 mmHg [8] Increase in PaCO2 [8] Difference between EtCO2 and PaCO2>10 mmHg [6] Increase in EtN2>0.04% [8] Hypoxia [8] Moderate 0.5-2.0 mL/kg Jugular venous distension [8,9] Unexplained hypotension [8,9] Hypoxia [8,9] ECG: tachyarrhythmias [8], right heart strain pattern (peaked P wave, RBBB, right axis deviation) [9,10] or acute ischaemia ST changes [8][9][10] Cerebral ischaemia (changes in mental status postoperatively) [8,10] Pulmonary hypertension detected via pulmonary artery catheter [6] Pulmonary oedema [9,10] Large>2.0 mL/kg 'Water-wheel' or 'mill-wheel' murmur [8,10] Acute-onset right-sided heart failure [8,9] Cardiovascular collapse [8,9] Cardiac arrest [9] Fatal at 3-4 mL/kg [8,10]…”