Intraoperative β− detecting probe for radio-guided surgery in tumour resection

Abstract

The development of the β − based radio-guided surgery aims to extend the technique to those tumours where surgery is the only possible treatment and the assessment of the resection would most profit from the low background around the lesion, as for brain tumours. Feasibility studies on meningioma and gliomas already estimated the potentiality of this new treatment. To validate the technique, a prototype of the intraoperative probe detecting β − decays and specific phantoms simulating tumour remnant patterns embedded in healthy tissue have been realized. The response of the probe in this simulated environment is tested with dedicated procedures. This document discusses the innovative aspects of the method, the status of the developed intraoperative β − detecting probe and the results of the preclinical tests.

Stability and efficiency of a CMOS sensor as detector of low energy β and γ particles

“…Extensive tests of this scintillating-detector have been performed on pure 𝛽 − emitters, like 90 Sr, which emits a 0.546 MeV electron decaying in 90 Y, which in turn emits a 2.28 MeV electron [4][5][6][7]. A feasibility study [8], based on Monte Carlo simulations, suggested the possibility to use also 2020 JINST 15 P11003 other isotopes like 31 Si, 32 P, 97 Zr and 168 Re.…”

Design optimization and performances of an intraoperative positron imaging probe for radioguided cancer surgery

“…Furthermore, the increasing 2016 JINST 11 P12019 number of positron or electron-emitting pharmaceuticals for diagnosis or therapeutic purposes has created a renewed interest for in situ detection of beta particles to perform real time delineation of tumor boundaries. Several preclinical or clinical studies have already shown the clinical potential of this technique through its ability to detect small radiolabeled tumor foci with dimensions less than 5 mm [11][12][13][14][15][16][17]. Compared to gamma detection, the short range of beta particles (around 1 mm in water for positron of 18 F [18]), allows a more sensitive and accurate tumor localization.…”