Intraoperatively local infiltration anesthesia in hemiarthroplasty patients reduces the needs of opioids: a randomized, double-blind, placebo-controlled trial with 96 patients in a fast-track hip fracture setting

Abstract

Background and purpose — Local infiltration analgesia (LIA) is commonly used as a component in multimodal analgesia. Pain management directed towards hip fracture patients operated on with hemiarthroplasty is often based on knowledge regarding pain treatment following elective surgery. In this elderly patient population, it is of value to clarify whether adding local infiltration analgesia (LIA) to the postoperative analgesic regimen might reduce postoperative pain or have an opioid-reducing effect. Patients and methods — 96 hip fracture patients undergoing hemiarthroplasty in spinal anesthesia were included. All patients received a multimodal pain regimen and were randomized to receive either ropivacaine or placebo. All patients received morphine depot-opioid and morphine as rescue medication postoperatively. The primary endpoint was pain during mobilization in the recovery unit on the day of surgery. Secondary endpoints were pain during mobilization the day after surgery and postoperative opioid requirements on the first postoperative day. Results — The levels of pain (NRS) during mobilization both in the recovery unit and on the day after surgery were similar in the 2 groups, with median 4 and 0.5 in the placebo group and median 3.5 and 1 in the ropivacaine group respectively. Total consumption of opioids on day 0 and day 1 were 4.6 mg lower in the ropivacaine group (p = 0.04). Pain during mobilization was registered for only 44 of 96 patients for several reasons, including lack of mobilization. Interpretation — There were similar pain scores in both the local infiltration and placebo group postoperatively. However, substantially reduced opioid consumption was found in patients receiving LIA.

Efficacy of local infiltration analgesia on recovery after total hip arthroplasty using direct anterior approach under spinal anaesthesia: a randomized, double-blind, placebo-controlled trial

“…In order to confirm Kerr and Kohan's findings, several studies have been executed. Conflicting evidence has been reported [2][3][4][5][6]8,9,11,12,[14][15][16][17][18][19] . However, consulting and summarizing the literature to date, The Enhanced Recovery consumption of piritramide or tramadol, but an analysis of binary results whether the patients had taken opioids at all.…”

“…Multiple studies have been conducted reporting contradictory results regarding the efficacy of LIA in hip arthroplasty [2][3][4][5][6]8,11,12,14,15,19,21,22 . However, as only recent studies have implemented an anterior approach, more research is advocated.…”

Pain intensity profile after a single injection of the peptide analgesic taphalgin in traumatology and orthopedic patients: prospective observational cohort study

“…3 динамика интенсивности боли обеспечена действием именно тафалгина. Такой принцип анализа анальгетической эффективности все чаще встречается в профессиональной литературе [12]. Обращает на себя внимание достаточно быстрый обезболивающий эффект, при котором начало действия отмечается уже через 15 мин после введения препарата, а медиана максимальной анальгетической активности составляет 40 мин.…”

Implementation of a Fascia Iliaca Compartment Block Program in Geriatric Hip Fractures: The Experience at a Level I Academic Trauma Center

“…Basmajian et al demonstrated a postoperative pain improvement after the administration of liposomal bupivacaine, and similarly, more recent studies have demonstrated the same. 32–34 Other cocktails like those used in arthroplasty may also be of benefit. 31,35,36 A paucity of evidence exists within the literature exploring these options, representing an area for further study as these cocktails may be used in lieu of or as part of the continuum of pain control.…”