2017
DOI: 10.1007/s12105-017-0810-5
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Intraoral Salivary Duct Cyst: Clinical and Histopathologic Features of 177 Cases

Abstract: The salivary duct cyst (SDC) is a reactive ductal ectasia most frequently seen in major salivary glands, and likely caused by obstruction. The aim of this study is to define the clinical and histopathologic spectrum of intraoral SDCs. Cases were retrieved from the archives of Harvard School of Dental Medicine/StrataDx, Inc. from January 2012 to August 2014. There were 177 cases of which 103 (58.2%) occurred in females, with a median age of 56 (range 2-95). Approximately half of cases (45.8%) presented in the a… Show more

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Cited by 34 publications
(31 citation statements)
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“…The non-neoplastic lesions that most closely overlap with true tumors are salivary duct cysts, also known as mucous retention cysts. These cysts, which are thought to represent dilation of the salivary duct system secondary to obstruction, can demonstrate a wide range of metaplastic changes, most notably including mucinous metaplasia with well-developed goblet cell formation [46]. Importantly, even though a significant subset of salivary duct cysts can show irregularities and undulations of their walls, the absence of complex glandular architecture or infiltrative growth can help distinguish them from MEC (Fig.…”
Section: Challenge #3: Mucin Productionmentioning
confidence: 99%
“…The non-neoplastic lesions that most closely overlap with true tumors are salivary duct cysts, also known as mucous retention cysts. These cysts, which are thought to represent dilation of the salivary duct system secondary to obstruction, can demonstrate a wide range of metaplastic changes, most notably including mucinous metaplasia with well-developed goblet cell formation [46]. Importantly, even though a significant subset of salivary duct cysts can show irregularities and undulations of their walls, the absence of complex glandular architecture or infiltrative growth can help distinguish them from MEC (Fig.…”
Section: Challenge #3: Mucin Productionmentioning
confidence: 99%
“…Unlike a mucocele that is surrounded by granulation tissue and/or fibrosis, a salivary duct cyst is lined by epithelium (true cyst). They are lined by 1-2 layers of cuboidal/columnar epithelium showing varying types of metaplasia (oncocytic, mucous cell, squamous, sebaceous, ciliated, apocrine-like) [23]. Papillary proliferation may rarely be seen, and should be separated from a cystadenoma [24].…”
Section: Non-neoplastic Mucus Cystsmentioning
confidence: 99%
“…Intraoral salivary duct cysts are acquired masses due to the obstruction of a major or minor salivary gland. They are typically characterized by columnar or cuboidal epithelium, though they may show squamous metaplasia [4]. Imaging in our patient did not show any obstructions or abnormalities of the salivary glands, making this diagnosis less plausible.…”
Section: Discussionmentioning
confidence: 68%