Intraosseous mandibular xanthomas – an interesting diagnostic dilemma?

Whitehouse, Laura Le.; Bobinskas, Alexander M.; Chengot, Preetha; Ong, T.K.

doi:10.1111/ors.12323

Cited by 3 publications

(18 citation statements)

References 19 publications

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“…Glycaemia levels were reported in five studies and lipidemia levels in 12, being within normal limits in all cases. Only one study demonstrated a case of IOX of the jaws with hyperlipidaemia.…”

Section: Resultsmentioning

confidence: 77%

“…After the elimination of 192 duplicates, the parameters for inclusion and exclusion were applied to 442 references. A total of 16 articles reporting 31 cases of IOX of the jaws were selected . The studies included in the present literature review were case reports or case series.…”

Section: Resultsmentioning

confidence: 99%

“…The studies included in the present literature review were case reports or case series. The articles were from the US, Canada, Brazil, Sweden, the Netherlands, Spain, the UK, Japan and Australia …”

Section: Resultsmentioning

confidence: 99%

“…Treatment consisted of curettage (83.9%). Among the 29 cases with information available, only one exhibited recurrence. Overall, the follow‐up period ranged from six to 216 months, with a median of 24 months (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Thus far, few cases of IOX of the jaws with enough clinicopathologic and radiographic details to confirm the diagnosis have been documented in the literature . Since case series of IOX of the jaws are infrequent in the literature, in order to provide consistent and well‐documented reports that may serve as a basis for a better understanding of the lesion, we describe here a series of five new cases of IOX of the mandible in a multi‐institutional study, with emphasis on clinicopathological, radiographic and immunohistochemical data of this condition as compared with reports detected in a literature review.…”

Section: Introductionmentioning

confidence: 92%

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Intraosseous xanthoma of the mandible: A multi‐institutional case series with a literature review

Arruda

Almeida

Abreu

et al. 2019

J Oral Pathology Medicine

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Background The aim of the present study was to report the clinicopathologic, radiographic and immunohistochemical features of five South American cases of intraosseous xanthomas of the mandible and to compare them to those detected in a literature review. Methods Clinical data were collected from the records of three Oral and Maxillofacial Pathology services in South America and compared with those compiled from a literature review based on a search of three electronic databases (PubMed, Web of Science and Scopus). All cases were evaluated by haematoxylin and eosin staining and immunohistochemistry for CD68 and S‐100. Results The series comprised four females (80%) and one male (20%) with a mean age of 23.3 ± 10.9 years (range: 13‐45 years). In four cases, there was involvement of the posterior region of the mandible (80%). The lesions presented radiographically as unilocular (60%) radiolucencies with punched‐out margin (80%). All cases predominantly consisted of CD68‐positive and S‐100‐negative xanthomatous cells. No recurrences were observed after curettage, with a median follow‐up of 27 months. Conclusion Intraosseous xanthoma of the jaws is a rare benign disorder. We report here five additional cases affecting the mandible, for a total of 36 cases of the jaws reported in the literature. Overall, this lesion has predilection for posterior sites of the mandible of asymptomatic young adults.

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Section: Resultsmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

See 3 more Smart Citations

Intraosseous xanthoma of the mandible: A multi‐institutional case series with a literature review

Arruda

Almeida

Abreu

et al. 2019

J Oral Pathology Medicine

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Xanthoma of the Jaw Bones: Cases Series and Review of Literature

Venkat,

Islam,

Bhattacharyya

et al. 2024

Head and Neck Pathol

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Background Intraosseous xanthomas are rare benign lesions sometimes associated with excess lipid production. Xanthoma of the jaw bones (XJB) was first reported in 1964, and fewer than 50 cases have been reported in the English literature to date. The etiopathogenesis of XJB is highly suggestive of a reactive process or a metabolic condition. Method Seven cases of XJBs were retrieved from the archives of 4 oral and maxillofacial pathology services. Clinical, radiographic and histopathologic features of all these cases were retrospectively analyzed. Immunohistochemical (IHC) stains for S100 and CD68 were performed. Results All seven cases involved the mandible. Patients’ age ranged between 13 and 69 years with an evenly distributed female to male ratio. One patient had a medical history of hyperlipidemia, but the medical and dental histories of the others were unremarkable. For most cases, XJB was an incidental finding discovered during routine radiographic examination. Swelling and cortical expansion were noted in a few cases. Radiographically, cases typically presented as either well-defined multilocular or unilocular lesions, which were either radiolucent or mixed radiolucent/radiopaque. All the lesions were treated with surgical curettage and no recurrence was observed during subsequent follow-ups. Each of the seven cases exhibited sheets of foamy macrophages. The diagnosis is established by exclusion of entities with overlapping microscopic features and involved correlation with the clinical, histological, radiographic and IHC profiles. Immunohistochemically, all the cases expressed diffuse positivity for CD68 and were negative for S100. Conclusion XJB is a rare lesion of unknown etiology, which may mimic other benign or reactive jaw lesions. Due to its rarity and the potential diagnostic challenges it presents, clinicians must remain vigilant and consider CXJ in their differential when assessing radiolucent jaw anomalies.

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