Intrapancreatic accessory spleen in a harbor porpoise (&lt;i&gt;Phocoena phocoena&lt;/i&gt;)

Nakagun, Shotaro; Díaz‐Delgado, Josué; Groch, Kátia R.; Kobayashi, Yoshiyasu

doi:10.1292/jvms.17-0691

Cited by 4 publications

(7 citation statements)

References 15 publications

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“…A poorly formed or deficient white pulp in the presence of a normal appearing red pulp has been previously described in humans ( 19 ). Furthermore, we report the presence of exocrine pancreatic acini embedded in the red pulp areas of the accessory splenic tissue, a novel histomorphological feature in IPAS, only reported, in the veterinary literature, in a harbor porpoise case ( Phocoena phocoena ) ( 16 ).…”

Section: Discussionmentioning

confidence: 83%

“…Microscopically, IPASs are structurally identical to the normal spleen, consisting of red and white pulp, but the presence of poorly formed or deficient white pulps and the absence of trabecular structures has been previously described in human accessory spleens ( 19 ). Therefore, the presence of accessory spleens poses a diagnostic challenge, requiring differentiation from other alterations such as haemorrhage, haematoma, haemal node, splenopancreatic fusion and endocrine or vascular tumors ( 16 , 20 , 21 ).…”

Section: Introductionmentioning

confidence: 99%

“…These lesions have a similar appearance to IPAS, so they could be misdiagnosed during experimental or field studies. Therefore, histological and immunohistochemical evaluation is essential to differentiate the origin of the lesions ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

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Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

Porras,

Chinchilla,

Rodríguez-Bertos

et al. 2023

Front. Vet. Sci.

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Intrapancreatic accessory spleen (IPAS) is one of the most frequent congenital splenic anomalies in humans; however, studies in veterinary medicine are scarce. This study aimed to describe the macroscopic, histopathological and immunohistochemical features of 11 suspected cases of IPAS in wild boar piglets of 3–4 months old. Seven of the 11 animals were immunised with a low virulence isolate of African swine fever virus (ASFV) and subsequently challenged with a highly virulent ASFV isolate (LVI-HVI group). The remaining four animals were exclusively infected with a highly virulent isolate of ASFV (HVI group). Grossly, lesions comprised focal or multifocal reddish areas of variable shape, located on the surface of the pancreatic tail or within the parenchyma. Histological and immunohistochemical studies (anti-CD79 and CD3) confirmed the presence of IPAS in eight of the 11 cases. IPAS shared the same histological structure and alterations as those observed in the original spleen. The immunohistochemical study against ASFV revealed the presence of VP72+ cells in both the spleen and IPAS of seven of the eight piglets. The results of this study describe for the first time the presence of IPAS in ASFV infection of wild boar (Sus scrofa) regardless the isolate and suggest that the infection may induce the development of ectopic splenic tissue due to an increased demand for phagocytic cells from the reticuloendothelial system. However, further studies are needed to understand the immunological mechanisms that trigger the formation of these accessory organs.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

Porras,

Chinchilla,

Rodríguez-Bertos

et al. 2023

Front. Vet. Sci.

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“…Eles são formados a partir defeitos durante a fase intrauterina. Apresentam estrutura e função imunológica semelhante à do baço principal [4][5][6][7][8][9][10][11][12][13][14][15][16][17] .…”

Section: Discussão De Casounclassified

Baço ectópico com hemangiossarcoma em cadela: relato de caso

Castro,

Silva,

Calejo

et al. 2023

Braz. J. Develop.

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Definisse baço ectópico quando encontrado tecido esplênico histologicamente normal em uma localização anormal, podendo ser classificado como um defeito congênito ou secundário. A forma congênita ocorre durante a formação embriológica do baço, causando uma separação de tecido esplênico, dando origem ao chamado, baço acessório. A forma secundária é uma autoimplantação de tecido esplênico em uma localização fora do baço principal ocorre após traumas ou cirurgia esplênica, dando origem a chamada, esplenose. Foi atendida uma cadela, da raça labrador, fêmea, com 9 anos para realização de ovariosalpingohisterectomia (OSH) eletiva, paciente estava assintomática. Durante o procedimento cirúrgico foi observado algumas estruturas arredondadas, de aspecto firme, localizadas em peritônio, foi coletado material para análise histopatológica confirmando o diagnóstico de esplenose. Após aproximadamente 1 ano da cirurgia, a paciente voltou ao hospital apresentando extensa formação em região de flanco do lado esquerdo acometendo musculatura, subcutâneo e se estendendo até a região abdominal ipsilateral. Foi realizado exame radiográfico, ultrassonográfico e tomográfico para planejamento cirúrgico. A paciente foi encaminhada para laparotomia exploratória, sendo feita a remoção da formação e nefrectomia esquerda devido a aderência formada nesta região. Foi feita a avaliação histológica onde concluiu-se quadro morfológico de formação esplênica compatível com Hemangiossarcoma Esplênico. Devido ao baço se apresentar preservado, sem nenhuma alteração macroscópia durante a laparotomia exploratória e sem alterações nos exames de imagem, correlacionamos o histórico prévio de esplenose encontrado na cirurgia de OSH e chegamos à conclusão que a esplenose tenha se desenvolvido e formado o hemangiossarcoma. O objetivo deste trabalho é elucidar a diferenciação de esplenose e baço acessório bem como relatar um caso de uma paciente com hemangiossarcoma em tecido esplênico ectópico (esplenose).

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“…Intrapancreatic splenic tissue (IPST) is sporadically reported in veterinary species, including dogs, 1 cats, 1,2 rabbits, 3,4 pigs, 5,6 cetaceans 7 and non-human primates. 8,9 IPST can have two possible origins, indistinguishable on histopathology: splenosis, which consists in autotransplantation of splenic tissue in a patient (ie, following trauma); or accessory spleen, which consists of aberrantly located splenic masses of congenital origin.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic and colour Doppler features of intrapancreatic splenic tissue in a cat

Peschard

Jamont

Shields

et al. 2022

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 2-year-old female neutered domestic longhair cat was referred for a 3-day history of lethargy and anorexia. Physical examination documented abdominal distension and pain, which, alongside marked electrolyte imbalances on blood biochemistry, was highly suspicious for a gastrointestinal obstruction. This was confirmed on diagnostic imaging, with abdominal ultrasonography also identifying an incidental, well-defined small lobular hypoechoic nodule adjacent to the tail of the spleen, with high vascularity on Doppler interrogation. This was identified as a focal nodule at the tip of the left limb of the pancreas at surgery, and resected via partial pancreatectomy. Histopathological examination confirmed intrapancreatic splenic tissue. Relevance and novel information This case report presents the first available ultrasonographic description and images of intrapancreatic splenic tissue in a cat. It is thought to be a benign lesion of low clinical significance and therefore defining its imaging characteristics may allow for improvement in diagnostic suspicion without resorting to excisional surgery.

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Intrapancreatic accessory spleen in a harbor porpoise (<i>Phocoena phocoena</i>)

Cited by 4 publications

References 15 publications

Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

Baço ectópico com hemangiossarcoma em cadela: relato de caso

Ultrasonographic and colour Doppler features of intrapancreatic splenic tissue in a cat

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