Intraparenchymal clear cell ependymoma

Deb, Prabal; Manu, V; Pradeep, H; Bhatoe, Harjinder S

doi:10.4103/0970-9371.80747

Cited by 8 publications

(24 citation statements)

References 9 publications

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“…The literature has also described more cases of ODG like clear cells present in anaplastic ependymoma Grade III rather than ependymoma Grade II. [ 6 8 13 22 28 30 ]…”

Section: Discussionmentioning

confidence: 99%

Ependymal tumors with oligodendroglioma like clear cells: Experience from a tertiary care hospital in Pakistan

Hashmi¹,

Khan²,

Waqas³

et al. 2015

Surg Neurol Int

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Background:Ependymal tumors with oligodendroglioma like clear cells have never been reported from Pakistan. We aimed to see the features and outcomes of this rare entity.Methods:It was retrospective cohort conducted at the Department of Neurosurgery, Aga Khan University from 2003 to 2013. The medical records and radiology of patients with proven histopathology were reviewed. Analysis was done on SPSS 20.Results:Eleven cases of ependymal tumors with clear cells were found, which equated to 1.5% of the total tumor burden in 11 years. The median age was 49 years. Most common presenting symptom was headache 54.5%. Out of 11 patients, 9 patients had a supratentorial tumor. Magnetic resonance imaging showed hypointense signals on T1 and hyperintense signals on T2-weighted images in all cases. Contrast enhancement was found in 9 patients (77.8%), necrosis and hemorrhage was found in 4 (36%) and 3 (27%) patients, respectively. Immunohistochemistry showed glial fibrillary acidic protein and epithelial membrane antigen positivity in all cases. Ki-67 showed high proliferative index in 6 patients. According to the World Health Organization grading of ependymal tumors, 2 patients had Grade II tumors, and 9 patients had Grade III tumors with clear cells. Gross total resection was achieved in 6 (54.5%) and subtotal resection in 5 patients (45.4%). Recurrence was observed in 9 patients. Six patients died of the disease. Median progression-free survival and overall survival was 8 months and 10 months, respectively.Conclusion:Ependymal tumors with clear cells presented more commonly in Grade III lesions and were more aggressive in behavior with poorer outcome compared to similar studies.

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“…The literature has also described more cases of ODG like clear cells present in anaplastic ependymoma Grade III rather than ependymoma Grade II. [ 6 8 13 22 28 30 ]…”

Section: Discussionmentioning

confidence: 99%

Ependymal tumors with oligodendroglioma like clear cells: Experience from a tertiary care hospital in Pakistan

Hashmi¹,

Khan²,

Waqas³

et al. 2015

Surg Neurol Int

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“…Immunohistochemically, CC‐EPN shows GFAP immunoreactivity 2 and EMA‐immunopositive intracytoplasmic dot‐like inclusions 3 . Furthermore, as seen in our case, supratentorial CC‐EPN tends to express L1CAM, suggesting the presence of C11orf95‐RELA fusion 3 .…”

Section: Discussionmentioning

confidence: 99%

Intracytoplasmic dot‐like inclusions as cytopathologically useful findings of ependymoma: Case report of adolescent supratentorial anaplastic ependymoma with clear cell morphology

Homma

Mizuno

Miyama

et al. 2020

Clinical Case Reports

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“…Clear cell along with tanycytic and papillary ependymoma represent three morphological ependymoma variants without prognostic significance . In limited biopsies, CCE may be mistaken for oligodendroglioma.…”

Section: Discussionmentioning

confidence: 99%

An Infratentorial Tumor in a 44‐Year‐Old Female Patient

Losa¹,

Carta²,

Frontzek³

et al. 2019

Brain Pathology

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A previously healthy 44-year-old female presented to the emergency department with sudden onset, bilateral throbbing headaches of two weeks duration. Three days prior to admission, she experienced several episodes of vomiting. Neurological examination was unremarkable and funduscopic examination showed no evidence of papilledema. CT and MRI of the head revealed a partially cystic, hemorrhagic mass with discrete calcifications in the cerebellomedulllary cistern with compression of the midbrain, of the foramina of Luschka bilaterally and of the foramen of Magendie. The radiographic differential diagnosis favored either subependymoma or medulloblastoma. The patient was admitted to the neurosurgical unit and underwent a craniotomy with gross total tumor resection. Postoperative recovery was unremarkable. MICROSCOPIC PATHOLOGYThe resected specimen consisted of multiple grey-white fragments with a slimy consistency and measured 0.9 x 0.7 x 0.6 cm in aggregate. Microscopically, the tumor was well-circumscribed and was organized into compact lobules separated by glial septa and thickened vessels. There was neither evidence of necrosis nor of microvascular proliferation. The back-to-back, monomorphic tumor cells harbored clear cytoplasm and contained large clefted nuclei ( Figure 1D). Perivascular rosettes were inconspicuous; however, occasional ependymal canals were visible. Immunohistochemical preparations for NHERF1/EBP50 highlighted ring-like microlumina and occasional dot-like and surface structures ( Figure 1E), whereas immunostain for EMA was negative. Mitotic figures were not observed and the MIB1 proliferation index was less than 3%. GFAP immunolabeled the glial septa and intermingled reactive astrocytes ( Figure 1F). In addition, the IHC panel showed negativity for CK8a, IDH, Synaptophysin, CD10, CKpanB, CD56 and Pax8. Ultrastructural examination revealed numerous intermediate (adherens) junctions as well as microvilli along cell borders ( Figure 1G). What is your diagnosis? Figure 1.

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Intraparenchymal clear cell ependymoma

Cited by 8 publications

References 9 publications

Ependymal tumors with oligodendroglioma like clear cells: Experience from a tertiary care hospital in Pakistan

Ependymal tumors with oligodendroglioma like clear cells: Experience from a tertiary care hospital in Pakistan

Intracytoplasmic dot‐like inclusions as cytopathologically useful findings of ependymoma: Case report of adolescent supratentorial anaplastic ependymoma with clear cell morphology

An Infratentorial Tumor in a 44‐Year‐Old Female Patient

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