Intraparotid and cervical lymph nodes metastasis in primary parotid gland carcinoma—impact on clinical outcome

Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review

“…Nineteen studies were included (Figure 1). 11‐13,20‐35 There were no prospective studies identified. Instead, all studies were retrospective and noncomparative trials.…”

“…One study collected data from two centers 25 . Twelve studies included all histological types of primary parotid cancer, 11‐13,20,21,26,27,29‐31,33,34 four studies were focused on mucoepidermoid cancer, 24,28,32,35 two studies on acinic cell carcinoma, 23,25 and one study on squamous cell carcinoma 22 . Two studies reported only pediatric cases 24,31 and one study focused only on early‐stage (low‐volume) cancer (T1/T2 N0M0) 33 .…”

“…Nine studies reported data on recurrence‐free survival 13,22,24,27‐29,31,32,35 . Nine studies provided data on overall survival 11,12,21‐24,27,29,30 . P+ was a significant negative prognostic factor for survival in all the multivariate regression models except one.…”

Parotid lymph nodes in primary malignant salivary neoplasms

“…Few studies have reported specifically on the identification and assessment of ‘parotid lymph nodes’ – peri-parotid or extraglandular and intraglandular nodes [41,56 ▪ ]. Only one report recorded their experience with imaging intraglandular lymph nodes in PMESGN, and lymph nodes identified in 28.5% (30/95) of patients studied, 20% (6/30) of cases of intraparotid lymph node-positive (IPLN+) were diagnosed based on clinical and imaging studies, whereas 80% (24/30) were diagnosed by histology [57] Therefore, one can conclude that identification of IPLN+ occurs either by intraoperative frozen section of a node recognized by the surgeon or by gross examination of the resected specimen, or at the time of the definitive evaluation of the fixed specimen with coincidental mention made in the final pathology report [40,58–61].…”

“…One study collected data from two centres [96]. Twelve studies included mixed histological types of primary parotid cancers [39,43,56 ▪ ,57,58,70,84,85,88,92,97,98], four studies were focused on mucoepidermoid carcinoma [91,93–95], two studies on acinic cell carcinoma [90,96] and one study on squamous cell carcinoma [89]. Two studies reported only paediatric cases [92,95] and one study focused only on early-stage (low-volume) cancer (T1/T2 N0M0) [85].…”