Intrapartum Hypomagnesemic Tetany: A Manifestation of an Ignored Element

Doctor, Jainesh; Bathija, Kunjal; Pardasani, Vibhor

doi:10.1007/s13224-018-1122-8

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…51 Intrapartum hypomagnesemia can cause tetany, which needs urgent intervention. 52 A de novo mutation (p.Leu328Val mutation) in the potassium voltage-gated channel subfamily A member 1 (KCNA1) gene encoding the voltage-gated potassium (K + ) channel Kv1.1 has been reported to cause hypomagnesemia and tetany. 53 Tetany from hypomagnesemia due to intestinal lymphangiectasia has also been reported.…”

Section: Pathophysiology Electrolytes and Acid-base Balancementioning

confidence: 99%

Spectrum of Disorders associated with Tetany

Santra¹

2023

JAPI

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Introduction: Awareness regarding the etiological spectrum of tetany is poor among physicians. Because of poor awareness, tetany is underdiagnosed and undertreated. Materials and methods: Databases like PubMed, PubMed Central, Scopus, and Google Scholar are searched to identify peer-reviewed articles on tetany. Case reports, case series, and original articles are analyzed to identify different causes of tetany prevalent in the community. Different causes found are analyzed and tabulated, and finally, a flowchart is made on the approach for diagnosing different underlying pathologies of tetany. Results: Both metabolic and respiratory alkalosis are important causes of tetany because of reduced ionized calcium levels. Gitelman syndrome (GS) is associated with metabolic alkalosis, hypokalemia, hypomagnesemia and hypocalciuria, and frequently causes normocalcemic tetany. Recurrent vomiting and primary hyperaldosteronism also cause tetany due to metabolic alkalosis. Hyperventilation syndrome (HVS) leads to respiratory alkalosis and is a frequent cause of tetany. Hyperventilation-induced tetany is also seen after spinal anesthesia and in respiratory disorders like asthma. Vitamin D deficiency (VDD), primary hypoparathyroidism, and pseudohypoparathyroidism (PHP) (1a, 1b, and 2) cause hypocalcemic tetany. Hypomagnesemia causes hypocalcemia and tetany due to peripheral parathyroid hormone resistance and impaired parathyroid hormone secretion. Drugs causing tetany include bisphosphonates, denosumab, cisplatin, antiepileptics, aminoglycosides, diuretics, etc. Tetany is also seen in acute pancreatitis, dengue, falciparum malaria, hyperemesis gravidarum, tumor lysis syndrome (TLS), massive blood transfusion, etc. Conclusion: The spectrum of disorders associated with tetany is diverse. Awareness of different causes will help early and proper diagnosis of tetany.

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Section: Pathophysiology Electrolytes and Acid-base Balancementioning

confidence: 99%

Spectrum of Disorders associated with Tetany

Santra¹

2023

JAPI

View full text Add to dashboard Cite

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Intrapartum Hypomagnesemic Tetany: A Manifestation of an Ignored Element

Cited by 1 publication

References 6 publications

Spectrum of Disorders associated with Tetany

Spectrum of Disorders associated with Tetany

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