Intrapatient variability in concentration/dose ratio of tacrolimus predicts transplant-associated thrombotic microangiopathy

Sagou, Ken; Fukushima, Norishige; Ukai, Shun; Goto, Miyo; Ozeki, Kazutaka; Kohno, Akio

doi:10.1007/s12185-020-02986-8

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Following surgery, the administration of immunosuppressive medication (received intra-and postoperatively) might also play a role in the development of renal failure. The tacrolimus level from initiation to cessation on D4 due to AKI never exceeded 7 mcg/L, so a microangiopathic cause due to the treatment is highly unlikely, as this tends to occur at levels above 11.4 mcg/L (Table 2) [14]. In this case, renal function was most likely modified by the hemodynamic changes during the procedure, such as the decrease in mean arterial pressure and cardiac output as well as the increase in renal venous pressure.…”

Section: Discussionmentioning

confidence: 99%

From Normal Renal Function to Renal Replacement Therapy after Liver Transplantation: A Case Report

Mangold,

Albu,

Maillard

et al. 2024

Transplantology

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Postoperative renal failure significantly impacts long-term renal function and the overall survival of patients receiving liver transplantation (LT), being a crucial factor in their morbidity and mortality. It is difficult to define whether the causes of renal failure are solely related to surgery or anaesthesia during liver transplantation (LT). Indeed, liver disease requiring liver transplantation is often the cause of preoperative renal failure. We report a case of a 62-year-old patient undergoing LT for cholangiocarcinoma that led to acute kidney injury postoperatively while his preoperative renal function was normal. This report highlights the major influence that the surgical and anaesthetic procedure can have on renal function and identifies the factors that may have led to renal replacement therapy being required for this patient.

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Section: Discussionmentioning

confidence: 99%